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- NCIT_C185677 IAO_0000115 "A T-cell-engaging, humanized, Fc-silenced immunoglobulin G1 (IgG1)-based bispecific antibody directed against both the tumor-associated antigen (TAA) FLT3 tyrosine kinase receptor (Fms-like tyrosine kinase 3; FLT3; FLT-3; CD135; fetal liver kinase-2; FLK2) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-FLT3/CD3 bispecific antibody CLN-049 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and FLT3 found on FLT3-expressing tumor cells. This activates and redirects CTLs to FLT3-expressing tumor cells, which results in the CTL-mediated cell death of FLT3-expressing tumor cells. FLT3, a cytokine receptor belonging to the class III tyrosine kinase receptors, is overexpressed or mutated in most B-lineage and acute myeloid leukemias (AMLs)." @default.
- NCIT_C185677 NCIT_A7 NCIT_C26202 @default.
- NCIT_C185677 NCIT_NHC0 "C185677" @default.
- NCIT_C185677 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185677 NCIT_P107 "Anti-FLT3/CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 NCIT_P108 "Anti-FLT3/CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 NCIT_P208 "CL1773849" @default.
- NCIT_C185677 NCIT_P322 "CTRP" @default.
- NCIT_C185677 NCIT_P322 "GDC" @default.
- NCIT_C185677 NCIT_P399 "809239" @default.
- NCIT_C185677 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185677 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185677 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185677 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185677 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185677 normalizedInformationContent "100" @default.
- NCIT_C185677 referenceCount "1" @default.
- NCIT_C185677 hasExactSynonym "Anti-FLT3/Anti-CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 hasExactSynonym "Anti-FLT3/CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 hasExactSynonym "CLN 049" @default.
- NCIT_C185677 hasExactSynonym "CLN-049" @default.
- NCIT_C185677 hasExactSynonym "CLN049" @default.
- NCIT_C185677 hasExactSynonym "FLT3 x CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 hasExactSynonym "FLT3 x CD3 Bispecific T Cell Engager CLN-049" @default.
- NCIT_C185677 inSubset NCIT_C116977 @default.
- NCIT_C185677 inSubset NCIT_C116978 @default.
- NCIT_C185677 inSubset NCIT_C128784 @default.
- NCIT_C185677 inSubset NCIT_C157711 @default.
- NCIT_C185677 inSubset NCIT_C157712 @default.
- NCIT_C185677 inSubset NCIT_C176424 @default.
- NCIT_C185677 type Class @default.
- NCIT_C185677 isDefinedBy ncit.owl @default.
- NCIT_C185677 label "Anti-FLT3/CD3 Bispecific Antibody CLN-049" @default.
- NCIT_C185677 subClassOf NCIT_C112883 @default.
- NCIT_C185677 subClassOf NCIT_C1454 @default.
- NCIT_C185677 subClassOf NCIT_C163758 @default.
- NCIT_C185677 subClassOf NCIT_C163790 @default.
- NCIT_C185677 subClassOf NCIT_C185677 @default.
- NCIT_C185677 subClassOf NCIT_C1908 @default.
- NCIT_C185677 subClassOf NCIT_C1909 @default.
- NCIT_C185677 subClassOf NCIT_C201282 @default.
- NCIT_C185677 subClassOf NCIT_C20401 @default.
- NCIT_C185677 subClassOf NCIT_C274 @default.
- NCIT_C185677 subClassOf NCIT_C28227 @default.
- NCIT_C185677 subClassOf NCIT_C307 @default.
- NCIT_C185677 subClassOf NCIT_C308 @default.