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- NCIT_C185861 IAO_0000115 "A human monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody NBL-015 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may trigger antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cell mediated phagocytosis (ADCP) and antibody-mediated complement dependent cytotoxicity (CDC). This may kill CLDN18.2-expressing tumor cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C185861 NCIT_A7 NCIT_C150412 @default.
- NCIT_C185861 NCIT_NHC0 "C185861" @default.
- NCIT_C185861 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185861 NCIT_P108 "Anti-Claudin-18.2 Monoclonal Antibody NBL-015" @default.
- NCIT_C185861 NCIT_P208 "CL1778269" @default.
- NCIT_C185861 NCIT_P322 "GDC" @default.
- NCIT_C185861 NCIT_P399 "808527" @default.
- NCIT_C185861 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185861 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185861 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185861 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185861 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185861 normalizedInformationContent "100" @default.
- NCIT_C185861 referenceCount "1" @default.
- NCIT_C185861 hasExactSynonym "Anti-CLDN18.2 Monoclonal Antibody NBL-015" @default.
- NCIT_C185861 hasExactSynonym "Anti-Claudin-18.2 Monoclonal Antibody NBL-015" @default.
- NCIT_C185861 hasExactSynonym "NBL 015" @default.
- NCIT_C185861 hasExactSynonym "NBL-015" @default.
- NCIT_C185861 hasExactSynonym "NBL015" @default.
- NCIT_C185861 inSubset NCIT_C128784 @default.
- NCIT_C185861 inSubset NCIT_C157711 @default.
- NCIT_C185861 inSubset NCIT_C157712 @default.
- NCIT_C185861 inSubset NCIT_C176424 @default.
- NCIT_C185861 type Class @default.
- NCIT_C185861 isDefinedBy ncit.owl @default.
- NCIT_C185861 label "Anti-Claudin-18.2 Monoclonal Antibody NBL-015" @default.
- NCIT_C185861 subClassOf NCIT_C129821 @default.
- NCIT_C185861 subClassOf NCIT_C129822 @default.
- NCIT_C185861 subClassOf NCIT_C163758 @default.
- NCIT_C185861 subClassOf NCIT_C179676 @default.
- NCIT_C185861 subClassOf NCIT_C185861 @default.
- NCIT_C185861 subClassOf NCIT_C1908 @default.
- NCIT_C185861 subClassOf NCIT_C1909 @default.
- NCIT_C185861 subClassOf NCIT_C200250 @default.
- NCIT_C185861 subClassOf NCIT_C20401 @default.
- NCIT_C185861 subClassOf NCIT_C274 @default.
- NCIT_C185861 subClassOf NCIT_C307 @default.
- NCIT_C185861 subClassOf NCIT_C308 @default.