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- NCIT_C185862 IAO_0000115 "The maleate salt form of flonoltinib, an orally bioavailable dual inhibitor of both Janus-associated kinase 2 (JAK2) and of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential anti-inflammatory, immunomodulating and antineoplastic activities. Upon oral administration, flonoltinib targets, binds to and inhibits the activity of both JAK2 and FLT3. This prevents the activation of the JAK/signal transducer and activator of transcription (STAT) signaling pathway and the activation of STAT3 and STAT5 as well as FLT3-mediated signaling. This may lead to an induction of apoptosis and a decrease in proliferation of tumor cells in which JAK2 and FLT3 are overexpressed. In addition, as JAK2 and FLT3 play a key role in the regulation of the inflammatory response and dendritic cell (DC) proliferation, differentiation and function, inhibition of JAK2- and FLT3-mediated signaling may suppress the generation and differentiation of DCs, and may regulate inflammatory and immune responses. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias." @default.
- NCIT_C185862 NCIT_A7 NCIT_C26202 @default.
- NCIT_C185862 NCIT_A7 NCIT_C28494 @default.
- NCIT_C185862 NCIT_NHC0 "C185862" @default.
- NCIT_C185862 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185862 NCIT_P108 "Flonoltinib Maleate" @default.
- NCIT_C185862 NCIT_P208 "CL1778270" @default.
- NCIT_C185862 NCIT_P322 "GDC" @default.
- NCIT_C185862 NCIT_P399 "808528" @default.
- NCIT_C185862 normalizedInformationContent "100" @default.
- NCIT_C185862 referenceCount "1" @default.
- NCIT_C185862 hasExactSynonym "Flonoltinib Maleate" @default.
- NCIT_C185862 inSubset NCIT_C128784 @default.
- NCIT_C185862 inSubset NCIT_C157711 @default.
- NCIT_C185862 inSubset NCIT_C157712 @default.
- NCIT_C185862 inSubset NCIT_C176424 @default.
- NCIT_C185862 type Class @default.
- NCIT_C185862 isDefinedBy ncit.owl @default.
- NCIT_C185862 label "Flonoltinib Maleate" @default.
- NCIT_C185862 subClassOf NCIT_C124800 @default.
- NCIT_C185862 subClassOf NCIT_C125450 @default.
- NCIT_C185862 subClassOf NCIT_C129824 @default.
- NCIT_C185862 subClassOf NCIT_C129825 @default.
- NCIT_C185862 subClassOf NCIT_C1404 @default.
- NCIT_C185862 subClassOf NCIT_C163758 @default.
- NCIT_C185862 subClassOf NCIT_C163790 @default.
- NCIT_C185862 subClassOf NCIT_C172200 @default.
- NCIT_C185862 subClassOf NCIT_C185862 @default.
- NCIT_C185862 subClassOf NCIT_C1908 @default.
- NCIT_C185862 subClassOf NCIT_C1909 @default.
- NCIT_C185862 subClassOf NCIT_C1967 @default.
- NCIT_C185862 subClassOf NCIT_C2189 @default.
- NCIT_C185862 subClassOf NCIT_C274 @default.
- NCIT_C185862 subClassOf NCIT_C471 @default.