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- NCIT_C185863 IAO_0000115 "An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor BLU-701 targets, reversibly binds to and inhibits the activity of the activating/ sensitizing mutations EGFR exon 19 deletion (ex19del) and L858R, and the C797S resistance EGFR mutations, including the resistance double mutants ex19del/C797S and L858R/C797S. This prevents EGFR mutant-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR mutant-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumors, plays a key role in tumor cell proliferation and tumor vascularization. BLU-701 is able to penetrate the blood-brain-barrier (BBB) and could exert its activity against CNS metastases in EGFR-driven tumors. BLU-701 does not inhibit the activity of wild-type (WT) EGFR." @default.
- NCIT_C185863 NCIT_A7 NCIT_C126892 @default.
- NCIT_C185863 NCIT_A7 NCIT_C147011 @default.
- NCIT_C185863 NCIT_A7 NCIT_C98515 @default.
- NCIT_C185863 NCIT_NHC0 "C185863" @default.
- NCIT_C185863 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185863 NCIT_P107 "EGFR Mutant-selective Inhibitor BLU-701" @default.
- NCIT_C185863 NCIT_P108 "EGFR Mutant-selective Inhibitor BLU-701" @default.
- NCIT_C185863 NCIT_P208 "CL1778244" @default.
- NCIT_C185863 NCIT_P322 "CTRP" @default.
- NCIT_C185863 NCIT_P322 "GDC" @default.
- NCIT_C185863 NCIT_P399 "808535" @default.
- NCIT_C185863 normalizedInformationContent "100" @default.
- NCIT_C185863 referenceCount "1" @default.
- NCIT_C185863 hasExactSynonym "BLU 701" @default.
- NCIT_C185863 hasExactSynonym "BLU-701" @default.
- NCIT_C185863 hasExactSynonym "BLU701" @default.
- NCIT_C185863 hasExactSynonym "EGFR Inhibitor BLU-701" @default.
- NCIT_C185863 hasExactSynonym "EGFR Mutant-selective Inhibitor BLU-701" @default.
- NCIT_C185863 hasExactSynonym "EGFR TKI BLU-701" @default.
- NCIT_C185863 inSubset NCIT_C116977 @default.
- NCIT_C185863 inSubset NCIT_C116978 @default.
- NCIT_C185863 inSubset NCIT_C128784 @default.
- NCIT_C185863 inSubset NCIT_C157711 @default.
- NCIT_C185863 inSubset NCIT_C157712 @default.
- NCIT_C185863 inSubset NCIT_C176424 @default.
- NCIT_C185863 type Class @default.
- NCIT_C185863 isDefinedBy ncit.owl @default.
- NCIT_C185863 label "EGFR Mutant-selective Inhibitor BLU-701" @default.
- NCIT_C185863 subClassOf NCIT_C129824 @default.
- NCIT_C185863 subClassOf NCIT_C129825 @default.
- NCIT_C185863 subClassOf NCIT_C1404 @default.
- NCIT_C185863 subClassOf NCIT_C163758 @default.
- NCIT_C185863 subClassOf NCIT_C163952 @default.
- NCIT_C185863 subClassOf NCIT_C185863 @default.
- NCIT_C185863 subClassOf NCIT_C1908 @default.
- NCIT_C185863 subClassOf NCIT_C1909 @default.
- NCIT_C185863 subClassOf NCIT_C1967 @default.
- NCIT_C185863 subClassOf NCIT_C2167 @default.
- NCIT_C185863 subClassOf NCIT_C2189 @default.
- NCIT_C185863 subClassOf NCIT_C274 @default.
- NCIT_C185863 subClassOf NCIT_C471 @default.