Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C185864> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C185864 IAO_0000115 "An orally bioavailable, irriversible inhibitor of menin, an essential co-factor of oncogenic menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion proteins, with potential antineoplastic activity. Upon oral administration, menin inhibitor BMF-219 specifically targets and binds to menin, thereby preventing the interaction between the two proteins menin and MLL and the formation of the menin-MLL complex. This reduces the expression of downstream target genes, such as MYC and Bcl2, and results in an inhibition of the proliferation of MLL-rearranged tumor cells. Menin, an essential transcriptional regulator, plays a key role in oncogenic signaling in cancers driven by oncogenic MLL-fusions." @default.
- NCIT_C185864 NCIT_A7 NCIT_C18051 @default.
- NCIT_C185864 NCIT_NHC0 "C185864" @default.
- NCIT_C185864 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185864 NCIT_P107 "Menin Inhibitor BMF-219" @default.
- NCIT_C185864 NCIT_P108 "Menin Inhibitor BMF-219" @default.
- NCIT_C185864 NCIT_P208 "CL1778245" @default.
- NCIT_C185864 NCIT_P322 "CTRP" @default.
- NCIT_C185864 NCIT_P322 "GDC" @default.
- NCIT_C185864 NCIT_P399 "808536" @default.
- NCIT_C185864 normalizedInformationContent "100" @default.
- NCIT_C185864 referenceCount "1" @default.
- NCIT_C185864 hasExactSynonym "BMF 219" @default.
- NCIT_C185864 hasExactSynonym "BMF-219" @default.
- NCIT_C185864 hasExactSynonym "BMF219" @default.
- NCIT_C185864 hasExactSynonym "Menin Inhibitor BMF-219" @default.
- NCIT_C185864 hasExactSynonym "Menin-MLL Interaction Inhibitor BMF-219" @default.
- NCIT_C185864 inSubset NCIT_C116977 @default.
- NCIT_C185864 inSubset NCIT_C116978 @default.
- NCIT_C185864 inSubset NCIT_C128784 @default.
- NCIT_C185864 inSubset NCIT_C157711 @default.
- NCIT_C185864 inSubset NCIT_C157712 @default.
- NCIT_C185864 inSubset NCIT_C176424 @default.
- NCIT_C185864 type Class @default.
- NCIT_C185864 isDefinedBy ncit.owl @default.
- NCIT_C185864 label "Menin Inhibitor BMF-219" @default.
- NCIT_C185864 subClassOf NCIT_C185864 @default.
- NCIT_C185864 subClassOf NCIT_C185877 @default.
- NCIT_C185864 subClassOf NCIT_C1908 @default.
- NCIT_C185864 subClassOf NCIT_C1909 @default.
- NCIT_C185864 subClassOf NCIT_C2189 @default.
- NCIT_C185864 subClassOf NCIT_C274 @default.