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- NCIT_C185865 IAO_0000115 "A bispecific antibody targeting Delta-like ligand 4 (DLL4) and vascular endothelial growth factor A (VEGF-A), with potential anti-angiogenic and antineoplastic activities. Upon administration, anti-DLL4/anti-VEGF-A bispecific antibody CTX-009 simultaneously targets, binds to and blocks DLL4 and VEGF-A. This prevents the activation of DLL-4/Notch- and VEGF-A/VEGF receptor (VEGFR)-mediated signaling pathways, which play key roles in angiogenesis and tumor vascularization. This prevents angiogenesis and may halt tumor cell proliferation. Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated to the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development. The expression of DLL4 is highly restricted to the vascular endothelium; DLL4/Notch signaling is required for the development of functional tumor blood vessels. VEGF-A is upregulated in a variety of cancer cell types and plays a crucial role in angiogenesis." @default.
- NCIT_C185865 NCIT_A7 NCIT_C20450 @default.
- NCIT_C185865 NCIT_A7 NCIT_C90319 @default.
- NCIT_C185865 NCIT_NHC0 "C185865" @default.
- NCIT_C185865 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185865 NCIT_P107 "Anti-DLL4/Anti-VEGF-A Bispecific Antibody CTX-009" @default.
- NCIT_C185865 NCIT_P108 "Anti-DLL4/Anti-VEGF-A Bispecific Antibody CTX-009" @default.
- NCIT_C185865 NCIT_P208 "CL1778246" @default.
- NCIT_C185865 NCIT_P322 "CTRP" @default.
- NCIT_C185865 NCIT_P322 "GDC" @default.
- NCIT_C185865 NCIT_P399 "808537" @default.
- NCIT_C185865 NCIT_R124 NCIT_C17710 @default.
- NCIT_C185865 NCIT_R124 NCIT_C17828 @default.
- NCIT_C185865 NCIT_R124 NCIT_C18219 @default.
- NCIT_C185865 NCIT_R124 NCIT_C19986 @default.
- NCIT_C185865 NCIT_R124 NCIT_C40474 @default.
- NCIT_C185865 normalizedInformationContent "100" @default.
- NCIT_C185865 referenceCount "1" @default.
- NCIT_C185865 hasExactSynonym "ABL 001" @default.
- NCIT_C185865 hasExactSynonym "ABL-001" @default.
- NCIT_C185865 hasExactSynonym "ABL001" @default.
- NCIT_C185865 hasExactSynonym "Anti-DLL4/Anti-VEGF-A Bispecific Antibody CTX-009" @default.
- NCIT_C185865 hasExactSynonym "Anti-DLL4/Anti-VEGF-A Bispecific Antibody ES104" @default.
- NCIT_C185865 hasExactSynonym "CTX 009" @default.
- NCIT_C185865 hasExactSynonym "CTX-009" @default.
- NCIT_C185865 hasExactSynonym "CTX009" @default.
- NCIT_C185865 hasExactSynonym "ES 104" @default.
- NCIT_C185865 hasExactSynonym "ES-104" @default.
- NCIT_C185865 hasExactSynonym "ES104" @default.
- NCIT_C185865 hasExactSynonym "NOV1501" @default.
- NCIT_C185865 hasExactSynonym "TR 009" @default.
- NCIT_C185865 inSubset NCIT_C116977 @default.
- NCIT_C185865 inSubset NCIT_C116978 @default.
- NCIT_C185865 inSubset NCIT_C128784 @default.
- NCIT_C185865 inSubset NCIT_C157711 @default.
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- NCIT_C185865 inSubset NCIT_C176424 @default.
- NCIT_C185865 type Class @default.
- NCIT_C185865 isDefinedBy ncit.owl @default.
- NCIT_C185865 label "Anti-DLL4/Anti-VEGF-A Bispecific Antibody CTX-009" @default.
- NCIT_C185865 subClassOf NCIT_C129821 @default.
- NCIT_C185865 subClassOf NCIT_C129822 @default.
- NCIT_C185865 subClassOf NCIT_C141144 @default.
- NCIT_C185865 subClassOf NCIT_C143250 @default.
- NCIT_C185865 subClassOf NCIT_C1454 @default.
- NCIT_C185865 subClassOf NCIT_C163758 @default.
- NCIT_C185865 subClassOf NCIT_C1742 @default.
- NCIT_C185865 subClassOf NCIT_C185865 @default.
- NCIT_C185865 subClassOf NCIT_C1908 @default.
- NCIT_C185865 subClassOf NCIT_C1909 @default.
- NCIT_C185865 subClassOf NCIT_C198860 @default.
- NCIT_C185865 subClassOf NCIT_C20401 @default.
- NCIT_C185865 subClassOf NCIT_C2496 @default.
- NCIT_C185865 subClassOf NCIT_C274 @default.
- NCIT_C185865 subClassOf NCIT_C28227 @default.
- NCIT_C185865 subClassOf NCIT_C307 @default.
- NCIT_C185865 subClassOf NCIT_C308 @default.