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- NCIT_C185869 IAO_0000115 "A vaccine consisting of a lipid nanoparticle (LNP) encapsulating four messenger RNAs (mRNAs) encoding the Epstein-Barr Virus (EBV) envelope glycoproteins gp42, gp220, gH and gL, with potential immunizing activity against EBV. Upon intramuscular administration of LNP-encapsulated EBV mRNA vaccine mRNA-1189, the LNP binds to the plasma membrane of cells and releases the mRNAs into the cells. The mRNAs are then translated by ribosomes to produce the EBV envelope glycoproteins. This may activate both humoral and cellular immune responses which may result in protection against EBV infection. EBV, a ubiquitous human herpes virus, is associated with infectious mononucleosis and various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas." @default.
- NCIT_C185869 NCIT_NHC0 "C185869" @default.
- NCIT_C185869 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185869 NCIT_P108 "Lipid Nanoparticle-encapsulated EBV mRNA Vaccine mRNA-1189" @default.
- NCIT_C185869 NCIT_P208 "CL1778250" @default.
- NCIT_C185869 NCIT_P322 "GDC" @default.
- NCIT_C185869 NCIT_P399 "808541" @default.
- NCIT_C185869 normalizedInformationContent "100" @default.
- NCIT_C185869 referenceCount "1" @default.
- NCIT_C185869 hasExactSynonym "Anti-EBV mRNA Vaccine mRNA-1189" @default.
- NCIT_C185869 hasExactSynonym "LNP-encapsulated EBV mRNA Vaccine mRNA-1189" @default.
- NCIT_C185869 hasExactSynonym "LNP-encapsulated mRNA-based EBV Vaccine mRNA-1189" @default.
- NCIT_C185869 hasExactSynonym "Lipid Nanoparticle-encapsulated EBV mRNA Vaccine mRNA-1189" @default.
- NCIT_C185869 hasExactSynonym "mRNA 1189" @default.
- NCIT_C185869 hasExactSynonym "mRNA-1189" @default.
- NCIT_C185869 hasExactSynonym "mRNA1189" @default.
- NCIT_C185869 inSubset NCIT_C128784 @default.
- NCIT_C185869 inSubset NCIT_C157711 @default.
- NCIT_C185869 inSubset NCIT_C157712 @default.
- NCIT_C185869 inSubset NCIT_C176424 @default.
- NCIT_C185869 type Class @default.
- NCIT_C185869 isDefinedBy ncit.owl @default.
- NCIT_C185869 label "Lipid Nanoparticle-encapsulated EBV mRNA Vaccine mRNA-1189" @default.
- NCIT_C185869 subClassOf NCIT_C129820 @default.
- NCIT_C185869 subClassOf NCIT_C1663 @default.
- NCIT_C185869 subClassOf NCIT_C172787 @default.
- NCIT_C185869 subClassOf NCIT_C181141 @default.
- NCIT_C185869 subClassOf NCIT_C185869 @default.
- NCIT_C185869 subClassOf NCIT_C1908 @default.
- NCIT_C185869 subClassOf NCIT_C1909 @default.
- NCIT_C185869 subClassOf NCIT_C274 @default.
- NCIT_C185869 subClassOf NCIT_C307 @default.
- NCIT_C185869 subClassOf NCIT_C308 @default.
- NCIT_C185869 subClassOf NCIT_C923 @default.