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- NCIT_C185870 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a chimeric anti-CD20 monoclonal antibody conjugated via a valine citrulline linker to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of anti-CD20 ADC MRG001, the monoclonal antibody moiety of MRG001 targets and binds to CD20 on the surfaces of tumor B-cells and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in CD20-expressing tumor cells. CD20 is a non-glycosylated cell surface phosphoprotein which is exclusively expressed on B-cells during most stages of B-cell development. It is often overexpressed in B-cell malignancies." @default.
- NCIT_C185870 NCIT_A7 NCIT_C38896 @default.
- NCIT_C185870 NCIT_NHC0 "C185870" @default.
- NCIT_C185870 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185870 NCIT_P108 "Anti-CD20 Antibody-drug Conjugate MRG001" @default.
- NCIT_C185870 NCIT_P208 "CL1778251" @default.
- NCIT_C185870 NCIT_P322 "GDC" @default.
- NCIT_C185870 NCIT_P399 "808538" @default.
- NCIT_C185870 normalizedInformationContent "100" @default.
- NCIT_C185870 referenceCount "1" @default.
- NCIT_C185870 hasExactSynonym "ADC MRG001" @default.
- NCIT_C185870 hasExactSynonym "Anti-CD20 ADC MRG001" @default.
- NCIT_C185870 hasExactSynonym "Anti-CD20 Antibody-drug Conjugate MRG001" @default.
- NCIT_C185870 hasExactSynonym "Anti-CD20/MMAE ADC MRG001" @default.
- NCIT_C185870 hasExactSynonym "MRG 001" @default.
- NCIT_C185870 hasExactSynonym "MRG-001" @default.
- NCIT_C185870 hasExactSynonym "MRG001" @default.
- NCIT_C185870 inSubset NCIT_C128784 @default.
- NCIT_C185870 inSubset NCIT_C157711 @default.
- NCIT_C185870 inSubset NCIT_C157712 @default.
- NCIT_C185870 inSubset NCIT_C176424 @default.
- NCIT_C185870 type Class @default.
- NCIT_C185870 isDefinedBy ncit.owl @default.
- NCIT_C185870 label "Anti-CD20 Antibody-drug Conjugate MRG001" @default.
- NCIT_C185870 subClassOf NCIT_C129821 @default.
- NCIT_C185870 subClassOf NCIT_C129823 @default.
- NCIT_C185870 subClassOf NCIT_C1512 @default.
- NCIT_C185870 subClassOf NCIT_C163758 @default.
- NCIT_C185870 subClassOf NCIT_C164034 @default.
- NCIT_C185870 subClassOf NCIT_C185870 @default.
- NCIT_C185870 subClassOf NCIT_C1908 @default.
- NCIT_C185870 subClassOf NCIT_C1909 @default.
- NCIT_C185870 subClassOf NCIT_C274 @default.
- NCIT_C185870 subClassOf NCIT_C307 @default.
- NCIT_C185870 subClassOf NCIT_C308 @default.