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- NCIT_C185871 IAO_0000115 "Exosome engineered to display the human pro-inflammatory cytokine interleukin-12 (IL-12) in a fully active form on the surface via the exosome surface glycoprotein prostaglandin F2 receptor negative regulator (PTGFRN; CD315), with potential immunostimulating and antineoplastic activities. Upon intralesional administration of IL-12-expressing exosome CDK-003, IL-12 expressed by the exosome may activate the immune system in the tumor microenvironment (TME) by promoting the activation of natural killer (NK) cells, inducing secretion of interferon-gamma (IFN-g) and inducing cytotoxic T-lymphocyte (CTL) responses against tumor cells. This may result in immune-mediated tumor cell death, inhibition of tumor cell proliferation and inhibition of tumor angiogenesis. The exosome-based formulation may provide targeted anti-tumor immunity while minimizing off-target toxicity. PTGFRN, expressed on the surface of the exosome, enables the engagement of the IL-12 receptor (IL-12R) on immune effector cells such as T-cells and NK cells." @default.
- NCIT_C185871 NCIT_A7 NCIT_C38915 @default.
- NCIT_C185871 NCIT_NHC0 "C185871" @default.
- NCIT_C185871 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185871 NCIT_P108 "IL-12-expressing Exosome CDK-003" @default.
- NCIT_C185871 NCIT_P208 "CL1778252" @default.
- NCIT_C185871 NCIT_P322 "GDC" @default.
- NCIT_C185871 NCIT_P399 "808539" @default.
- NCIT_C185871 normalizedInformationContent "100" @default.
- NCIT_C185871 referenceCount "1" @default.
- NCIT_C185871 hasExactSynonym "CDK 003" @default.
- NCIT_C185871 hasExactSynonym "CDK-003" @default.
- NCIT_C185871 hasExactSynonym "CDK003" @default.
- NCIT_C185871 hasExactSynonym "IL-12-displaying Therapeutic Exosome CDK-003" @default.
- NCIT_C185871 hasExactSynonym "IL-12-expressing Exosome CDK-003" @default.
- NCIT_C185871 hasExactSynonym "IL-12/PTGFRN-expressing Exosome CDK-003" @default.
- NCIT_C185871 hasExactSynonym "exoIL-12" @default.
- NCIT_C185871 inSubset NCIT_C128784 @default.
- NCIT_C185871 inSubset NCIT_C157711 @default.
- NCIT_C185871 inSubset NCIT_C157712 @default.
- NCIT_C185871 inSubset NCIT_C176424 @default.
- NCIT_C185871 type Class @default.
- NCIT_C185871 isDefinedBy ncit.owl @default.
- NCIT_C185871 label "IL-12-expressing Exosome CDK-003" @default.
- NCIT_C185871 subClassOf NCIT_C129820 @default.
- NCIT_C185871 subClassOf NCIT_C185871 @default.
- NCIT_C185871 subClassOf NCIT_C1908 @default.
- NCIT_C185871 subClassOf NCIT_C1909 @default.
- NCIT_C185871 subClassOf NCIT_C274 @default.
- NCIT_C185871 subClassOf NCIT_C308 @default.