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- NCIT_C185872 IAO_0000115 "A subcutaneous injectable suspension formulation containing the acetate salt form of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon subcutaneous administration of the leuprolide acetate for injectable suspension TOL2506, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In males, this results in a significant decline in testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. In females, this decreases estradiol production and level, suppresses ovarian function and may inhibit proliferation of estrogen receptor (ER)-positive breast cancer." @default.
- NCIT_C185872 NCIT_A7 NCIT_C38910 @default.
- NCIT_C185872 NCIT_NHC0 "C185872" @default.
- NCIT_C185872 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185872 NCIT_P107 "Leuprolide Acetate for Injectable Suspension TOL2506" @default.
- NCIT_C185872 NCIT_P108 "Leuprolide Acetate for Injectable Suspension TOL2506" @default.
- NCIT_C185872 NCIT_P208 "CL1778253" @default.
- NCIT_C185872 NCIT_P322 "CTRP" @default.
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- NCIT_C185872 NCIT_P399 "809601" @default.
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- NCIT_C185872 normalizedInformationContent "100" @default.
- NCIT_C185872 referenceCount "1" @default.
- NCIT_C185872 hasExactSynonym "Leuprolide Acetate for Injectable Suspension TOL2506" @default.
- NCIT_C185872 hasExactSynonym "TOL 2506" @default.
- NCIT_C185872 hasExactSynonym "TOL-2506" @default.
- NCIT_C185872 hasExactSynonym "TOL2506" @default.
- NCIT_C185872 inSubset NCIT_C116977 @default.
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- NCIT_C185872 inSubset NCIT_C176424 @default.
- NCIT_C185872 type Class @default.
- NCIT_C185872 isDefinedBy ncit.owl @default.
- NCIT_C185872 label "Leuprolide Acetate for Injectable Suspension TOL2506" @default.
- NCIT_C185872 subClassOf B0468632818a2f1c6f1b4bf4d7ded93cb @default.
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- NCIT_C185872 subClassOf NCIT_C548 @default.