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- NCIT_C185875 IAO_0000115 "An orally bioavailable degrader of casein kinase 1 alpha (CK1alpha; CK1a), with potential antineoplastic activity. Upon oral administration, CK1a degrader CC-91633 binds to and degrades CK1a, thereby inhibits the activity of CK1a. This prevents the enhanced binding of murine double minute X (MDMX) to p53, reduces the formation of CK1a and MDM2 complex, and prevents the interaction of MDM2 with p53. This prevents the inhibition of p53 and increases p53 activity. This induces p53-mediated cell cycle arrest, thereby inhibiting tumor cell proliferation. CK1a, a serine/threonine kinase and a leukemic stem cell target, acts as a tumor suppressor in several cancers through the negative regulation of Wnt/beta-catenin signaling and p53. It negatively regulates p53 by phosphorylating MDMX, thus enhancing binding of MDMX to p53, as well as by forming a complex with MDM2." @default.
- NCIT_C185875 NCIT_A7 NCIT_C26033 @default.
- NCIT_C185875 NCIT_NHC0 "C185875" @default.
- NCIT_C185875 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C185875 NCIT_P107 "CK1 Alpha Degrader CC-91633" @default.
- NCIT_C185875 NCIT_P108 "CK1 Alpha Degrader CC-91633" @default.
- NCIT_C185875 NCIT_P208 "CL1778256" @default.
- NCIT_C185875 NCIT_P322 "CTRP" @default.
- NCIT_C185875 NCIT_P322 "GDC" @default.
- NCIT_C185875 NCIT_P399 "809602" @default.
- NCIT_C185875 NCIT_R125 NCIT_C17828 @default.
- NCIT_C185875 NCIT_R125 NCIT_C20150 @default.
- NCIT_C185875 NCIT_R125 NCIT_C20480 @default.
- NCIT_C185875 NCIT_R125 NCIT_C40715 @default.
- NCIT_C185875 NCIT_R125 NCIT_C41515 @default.
- NCIT_C185875 NCIT_R125 NCIT_C51037 @default.
- NCIT_C185875 normalizedInformationContent "100" @default.
- NCIT_C185875 referenceCount "1" @default.
- NCIT_C185875 hasExactSynonym "BMS 986397" @default.
- NCIT_C185875 hasExactSynonym "BMS-986397" @default.
- NCIT_C185875 hasExactSynonym "BMS986397" @default.
- NCIT_C185875 hasExactSynonym "CC 91633" @default.
- NCIT_C185875 hasExactSynonym "CC-91633" @default.
- NCIT_C185875 hasExactSynonym "CC91633" @default.
- NCIT_C185875 hasExactSynonym "CK1 Alpha Degrader BMS986397" @default.
- NCIT_C185875 hasExactSynonym "CK1 Alpha Degrader CC-91633" @default.
- NCIT_C185875 hasExactSynonym "CK1a Degrader CC-91633" @default.
- NCIT_C185875 inSubset NCIT_C116977 @default.
- NCIT_C185875 inSubset NCIT_C116978 @default.
- NCIT_C185875 inSubset NCIT_C128784 @default.
- NCIT_C185875 inSubset NCIT_C157711 @default.
- NCIT_C185875 inSubset NCIT_C157712 @default.
- NCIT_C185875 inSubset NCIT_C176424 @default.
- NCIT_C185875 type Class @default.
- NCIT_C185875 isDefinedBy ncit.owl @default.
- NCIT_C185875 label "CK1 Alpha Degrader CC-91633" @default.
- NCIT_C185875 subClassOf B28d3e21eebe89d6516ed3b000a113d46 @default.
- NCIT_C185875 subClassOf Bb1579afc022949c8794f2b9f7ad4e777 @default.
- NCIT_C185875 subClassOf NCIT_C185875 @default.
- NCIT_C185875 subClassOf NCIT_C1908 @default.
- NCIT_C185875 subClassOf NCIT_C1909 @default.
- NCIT_C185875 subClassOf NCIT_C2189 @default.
- NCIT_C185875 subClassOf NCIT_C274 @default.