Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C1863> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- NCIT_C1863 IAO_0000115 "A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation." @default.
- NCIT_C1863 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1863 NCIT_A7 NCIT_C16682 @default.
- NCIT_C1863 NCIT_NHC0 "C1863" @default.
- NCIT_C1863 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1863 NCIT_P107 "Entinostat" @default.
- NCIT_C1863 NCIT_P108 "Entinostat" @default.
- NCIT_C1863 NCIT_P175 "706995" @default.
- NCIT_C1863 NCIT_P207 "C4048552" @default.
- NCIT_C1863 NCIT_P210 "209783-80-2" @default.
- NCIT_C1863 NCIT_P319 "1ZNY4FKK9H" @default.
- NCIT_C1863 NCIT_P322 "CTRP" @default.
- NCIT_C1863 NCIT_P322 "FDA" @default.
- NCIT_C1863 NCIT_P322 "GDC" @default.
- NCIT_C1863 NCIT_P325 "A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor." @default.
- NCIT_C1863 NCIT_P329 "38294" @default.
- NCIT_C1863 NCIT_P330 "38294" @default.
- NCIT_C1863 NCIT_P350 "C21H20N4O3" @default.
- NCIT_C1863 NCIT_P366 "MS-27-275" @default.
- NCIT_C1863 NCIT_P375 "Entinostat" @default.
- NCIT_C1863 NCIT_P399 "38294" @default.
- NCIT_C1863 normalizedInformationContent "100" @default.
- NCIT_C1863 referenceCount "1" @default.
- NCIT_C1863 hasExactSynonym "Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester" @default.
- NCIT_C1863 hasExactSynonym "Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)" @default.
- NCIT_C1863 hasExactSynonym "ENTINOSTAT" @default.
- NCIT_C1863 hasExactSynonym "Entinostat" @default.
- NCIT_C1863 hasExactSynonym "HDAC inhibitor SNDX-275" @default.
- NCIT_C1863 hasExactSynonym "MS 27-275" @default.
- NCIT_C1863 hasExactSynonym "MS-275" @default.
- NCIT_C1863 hasExactSynonym "N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide" @default.
- NCIT_C1863 hasExactSynonym "SNDX-275" @default.
- NCIT_C1863 hasExactSynonym "entinostat" @default.
- NCIT_C1863 inSubset NCIT_C116977 @default.
- NCIT_C1863 inSubset NCIT_C116978 @default.
- NCIT_C1863 inSubset NCIT_C128784 @default.
- NCIT_C1863 inSubset NCIT_C157711 @default.
- NCIT_C1863 inSubset NCIT_C157712 @default.
- NCIT_C1863 inSubset NCIT_C176424 @default.
- NCIT_C1863 inSubset NCIT_C177537 @default.
- NCIT_C1863 inSubset NCIT_C63923 @default.
- NCIT_C1863 type Class @default.
- NCIT_C1863 isDefinedBy ncit.owl @default.
- NCIT_C1863 label "Entinostat" @default.
- NCIT_C1863 subClassOf B09c273f5f26cf942bc443f3c261a0f18 @default.
- NCIT_C1863 subClassOf Bf3183cb6a350801927d3b8984f07f88b @default.
- NCIT_C1863 subClassOf NCIT_C163758 @default.
- NCIT_C1863 subClassOf NCIT_C1863 @default.
- NCIT_C1863 subClassOf NCIT_C1908 @default.
- NCIT_C1863 subClassOf NCIT_C1909 @default.
- NCIT_C1863 subClassOf NCIT_C1946 @default.
- NCIT_C1863 subClassOf NCIT_C274 @default.
- NCIT_C1863 subClassOf NCIT_C471 @default.