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- NCIT_C186368 IAO_0000115 "An antibody-drug conjugate (ADC) composed of an antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via a protease-cleavable peptide linker, with potential antineoplastic activity. Upon administration of the anti-PD-L1 ADC SGN-PDL1V, the anti-PD-L1 antibody specifically targets and binds to PD-L1 expressed on tumor cells. Following internalization, enzymatic cleavage and release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in PD-L1-expressing tumor cells. PD-L1, a transmembrane protein, is expressed on the surface of certain immune cells and on many cancer cell types. PD-L1 binding to PD-1, a negative regulator of the immune system on activated T-cells, limits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion." @default.
- NCIT_C186368 NCIT_A7 NCIT_C96024 @default.
- NCIT_C186368 NCIT_NHC0 "C186368" @default.
- NCIT_C186368 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186368 NCIT_P107 "Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V" @default.
- NCIT_C186368 NCIT_P108 "Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V" @default.
- NCIT_C186368 NCIT_P208 "CL1778586" @default.
- NCIT_C186368 NCIT_P322 "CTRP" @default.
- NCIT_C186368 NCIT_P322 "GDC" @default.
- NCIT_C186368 NCIT_P399 "809089" @default.
- NCIT_C186368 normalizedInformationContent "100" @default.
- NCIT_C186368 referenceCount "1" @default.
- NCIT_C186368 hasExactSynonym "Anti-PD-L1 ADC SGN-PDL1V" @default.
- NCIT_C186368 hasExactSynonym "Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V" @default.
- NCIT_C186368 hasExactSynonym "Anti-PD-L1 Vedotin ADC SGN-PDL1V" @default.
- NCIT_C186368 hasExactSynonym "SGN PDL1V" @default.
- NCIT_C186368 hasExactSynonym "SGN-PDL1V" @default.
- NCIT_C186368 hasExactSynonym "SGNPDL1V" @default.
- NCIT_C186368 inSubset NCIT_C116977 @default.
- NCIT_C186368 inSubset NCIT_C116978 @default.
- NCIT_C186368 inSubset NCIT_C128784 @default.
- NCIT_C186368 inSubset NCIT_C157711 @default.
- NCIT_C186368 inSubset NCIT_C157712 @default.
- NCIT_C186368 inSubset NCIT_C176424 @default.
- NCIT_C186368 type Class @default.
- NCIT_C186368 isDefinedBy ncit.owl @default.
- NCIT_C186368 label "Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V" @default.
- NCIT_C186368 subClassOf NCIT_C129821 @default.
- NCIT_C186368 subClassOf NCIT_C129823 @default.
- NCIT_C186368 subClassOf NCIT_C1512 @default.
- NCIT_C186368 subClassOf NCIT_C186368 @default.
- NCIT_C186368 subClassOf NCIT_C1908 @default.
- NCIT_C186368 subClassOf NCIT_C1909 @default.
- NCIT_C186368 subClassOf NCIT_C274 @default.
- NCIT_C186368 subClassOf NCIT_C307 @default.
- NCIT_C186368 subClassOf NCIT_C308 @default.