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- NCIT_C186370 IAO_0000115 "A humanized monoclonal antibody targeting the ectoenzyme 5'-ecto-nucleotidase (cluster of differentiation 73; CD73; 5'-NT; ecto-5'-nucleotidase; NT5E), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD73 monoclonal antibody JAB-BX102 targets and binds to CD73 on tumor cells, thereby inhibiting the activity of CD73. This prevents CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine and the adenosine-mediated suppression of lymphocyte activity and trafficking. This attenuates the adenosine-induced immunosuppression in the tumor microenvironment (TME), increases the activity of cytotoxic T-lymphocytes (CTLs), activates macrophages and reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes (Tregs). By abrogating the inhibitory effect on the immune system and enhancing the CTL-mediated immune response against cancer cells, tumor cell growth is decreased. CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase) family, is upregulated on a number of cancer cell types and catalyzes the conversion of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such as adenosine; it plays a key role in adenosine-mediated immunosuppression within the TME." @default.
- NCIT_C186370 NCIT_A7 NCIT_C114927 @default.
- NCIT_C186370 NCIT_NHC0 "C186370" @default.
- NCIT_C186370 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186370 NCIT_P108 "Anti-CD73 Monoclonal Antibody JAB-BX102" @default.
- NCIT_C186370 NCIT_P208 "CL1778588" @default.
- NCIT_C186370 NCIT_P322 "GDC" @default.
- NCIT_C186370 NCIT_P399 "809082" @default.
- NCIT_C186370 NCIT_R124 NCIT_C17710 @default.
- NCIT_C186370 NCIT_R124 NCIT_C17828 @default.
- NCIT_C186370 NCIT_R124 NCIT_C18219 @default.
- NCIT_C186370 NCIT_R124 NCIT_C19986 @default.
- NCIT_C186370 NCIT_R124 NCIT_C40474 @default.
- NCIT_C186370 normalizedInformationContent "100" @default.
- NCIT_C186370 referenceCount "1" @default.
- NCIT_C186370 hasExactSynonym "Anti-CD73 Monoclonal Antibody JAB-BX102" @default.
- NCIT_C186370 hasExactSynonym "JAB BX102" @default.
- NCIT_C186370 hasExactSynonym "JAB-BX102" @default.
- NCIT_C186370 hasExactSynonym "JABBX102" @default.
- NCIT_C186370 inSubset NCIT_C128784 @default.
- NCIT_C186370 inSubset NCIT_C157711 @default.
- NCIT_C186370 inSubset NCIT_C157712 @default.
- NCIT_C186370 inSubset NCIT_C176424 @default.
- NCIT_C186370 type Class @default.
- NCIT_C186370 isDefinedBy ncit.owl @default.
- NCIT_C186370 label "Anti-CD73 Monoclonal Antibody JAB-BX102" @default.
- NCIT_C186370 subClassOf NCIT_C129820 @default.
- NCIT_C186370 subClassOf NCIT_C129821 @default.
- NCIT_C186370 subClassOf NCIT_C129822 @default.
- NCIT_C186370 subClassOf NCIT_C176988 @default.
- NCIT_C186370 subClassOf NCIT_C186370 @default.
- NCIT_C186370 subClassOf NCIT_C1908 @default.
- NCIT_C186370 subClassOf NCIT_C1909 @default.
- NCIT_C186370 subClassOf NCIT_C201133 @default.
- NCIT_C186370 subClassOf NCIT_C20401 @default.
- NCIT_C186370 subClassOf NCIT_C274 @default.
- NCIT_C186370 subClassOf NCIT_C307 @default.
- NCIT_C186370 subClassOf NCIT_C308 @default.