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- NCIT_C186372 IAO_0000115 "A conditionally active biologic (CAB) and monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration and specific activation in the tumor microenvironment (TME) due to the unique microphysical conditions that are present in the TME, anti-CTLA-4 monoclonal antibody BA3071 targets and binds to CTLA-4 expressed on T-cells within the TME and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system. By using a CAB anti-CTLA-4 antibody, systemic toxicity may be reduced." @default.
- NCIT_C186372 NCIT_A7 NCIT_C17489 @default.
- NCIT_C186372 NCIT_NHC0 "C186372" @default.
- NCIT_C186372 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186372 NCIT_P108 "Anti-CTLA-4 Monoclonal Antibody BA3071" @default.
- NCIT_C186372 NCIT_P208 "CL1778590" @default.
- NCIT_C186372 NCIT_P322 "GDC" @default.
- NCIT_C186372 NCIT_P399 "809083" @default.
- NCIT_C186372 NCIT_R124 NCIT_C17710 @default.
- NCIT_C186372 NCIT_R124 NCIT_C17828 @default.
- NCIT_C186372 NCIT_R124 NCIT_C18219 @default.
- NCIT_C186372 NCIT_R124 NCIT_C19986 @default.
- NCIT_C186372 NCIT_R124 NCIT_C40474 @default.
- NCIT_C186372 normalizedInformationContent "100" @default.
- NCIT_C186372 referenceCount "1" @default.
- NCIT_C186372 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody BA3071" @default.
- NCIT_C186372 hasExactSynonym "BA 3071" @default.
- NCIT_C186372 hasExactSynonym "BA-3071" @default.
- NCIT_C186372 hasExactSynonym "BA3071" @default.
- NCIT_C186372 inSubset NCIT_C128784 @default.
- NCIT_C186372 inSubset NCIT_C157711 @default.
- NCIT_C186372 inSubset NCIT_C157712 @default.
- NCIT_C186372 inSubset NCIT_C176424 @default.
- NCIT_C186372 type Class @default.
- NCIT_C186372 isDefinedBy ncit.owl @default.
- NCIT_C186372 label "Anti-CTLA-4 Monoclonal Antibody BA3071" @default.
- NCIT_C186372 subClassOf NCIT_C128036 @default.
- NCIT_C186372 subClassOf NCIT_C141144 @default.
- NCIT_C186372 subClassOf NCIT_C143250 @default.
- NCIT_C186372 subClassOf NCIT_C163758 @default.
- NCIT_C186372 subClassOf NCIT_C186372 @default.
- NCIT_C186372 subClassOf NCIT_C1908 @default.
- NCIT_C186372 subClassOf NCIT_C1909 @default.
- NCIT_C186372 subClassOf NCIT_C191738 @default.
- NCIT_C186372 subClassOf NCIT_C20401 @default.
- NCIT_C186372 subClassOf NCIT_C274 @default.
- NCIT_C186372 subClassOf NCIT_C307 @default.
- NCIT_C186372 subClassOf NCIT_C308 @default.