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- NCIT_C186373 IAO_0000115 "An orally bioavailable selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD AND019 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells." @default.
- NCIT_C186373 NCIT_A7 NCIT_C38361 @default.
- NCIT_C186373 NCIT_NHC0 "C186373" @default.
- NCIT_C186373 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186373 NCIT_P108 "Selective Estrogen Receptor Degrader AND019" @default.
- NCIT_C186373 NCIT_P208 "CL1778591" @default.
- NCIT_C186373 NCIT_P322 "GDC" @default.
- NCIT_C186373 NCIT_P399 "809067" @default.
- NCIT_C186373 normalizedInformationContent "100" @default.
- NCIT_C186373 referenceCount "1" @default.
- NCIT_C186373 hasExactSynonym "AND 019" @default.
- NCIT_C186373 hasExactSynonym "AND-019" @default.
- NCIT_C186373 hasExactSynonym "AND019" @default.
- NCIT_C186373 hasExactSynonym "SERD AND019" @default.
- NCIT_C186373 hasExactSynonym "Selective Estrogen Receptor Degrader AND019" @default.
- NCIT_C186373 inSubset NCIT_C128784 @default.
- NCIT_C186373 inSubset NCIT_C157711 @default.
- NCIT_C186373 inSubset NCIT_C157712 @default.
- NCIT_C186373 inSubset NCIT_C176424 @default.
- NCIT_C186373 type Class @default.
- NCIT_C186373 isDefinedBy ncit.owl @default.
- NCIT_C186373 label "Selective Estrogen Receptor Degrader AND019" @default.
- NCIT_C186373 subClassOf NCIT_C129818 @default.
- NCIT_C186373 subClassOf NCIT_C147908 @default.
- NCIT_C186373 subClassOf NCIT_C163758 @default.
- NCIT_C186373 subClassOf NCIT_C186373 @default.
- NCIT_C186373 subClassOf NCIT_C1908 @default.
- NCIT_C186373 subClassOf NCIT_C1909 @default.
- NCIT_C186373 subClassOf NCIT_C2116 @default.
- NCIT_C186373 subClassOf NCIT_C274 @default.
- NCIT_C186373 subClassOf NCIT_C481 @default.
- NCIT_C186373 subClassOf NCIT_C547 @default.