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- NCIT_C186376 IAO_0000115 "An oncolytic adenovirus that has been genetically engineered to express interferon (IFN), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, the oncolytic adenovirus expressing IFN YSCH-01 selectively infects and replicates in tumor cells, leading to tumor cell lysis. In addition, tumor cell lysis releases a variety of tumor-associated antigens (TAAs), which may potentially result in the activation of a systemic immune response against the TAAs-expressing tumor cells. The IFN expressed by the oncolytic adenovirus also activates T-lymphocytes, dendritic cells (DCs) and natural killer (NK) cells and induces an anti-tumor immune response against the tumor cells." @default.
- NCIT_C186376 NCIT_NHC0 "C186376" @default.
- NCIT_C186376 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186376 NCIT_P108 "Oncolytic Adenovirus Expressing Interferon YSCH-01" @default.
- NCIT_C186376 NCIT_P208 "CL1778594" @default.
- NCIT_C186376 NCIT_P322 "GDC" @default.
- NCIT_C186376 NCIT_P399 "809112" @default.
- NCIT_C186376 normalizedInformationContent "100" @default.
- NCIT_C186376 referenceCount "1" @default.
- NCIT_C186376 hasExactSynonym "Oncolytic Adenovirus Expressing IFN YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "Oncolytic Adenovirus Expressing Interferon YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "Oncolytic Adenovirus YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "Oncolytic Virus YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "Recombinant Oncolytic Adenovirus L-IFN YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "YSCH 01" @default.
- NCIT_C186376 hasExactSynonym "YSCH-01" @default.
- NCIT_C186376 hasExactSynonym "YSCH01" @default.
- NCIT_C186376 inSubset NCIT_C128784 @default.
- NCIT_C186376 inSubset NCIT_C157711 @default.
- NCIT_C186376 inSubset NCIT_C157712 @default.
- NCIT_C186376 inSubset NCIT_C176424 @default.
- NCIT_C186376 type Class @default.
- NCIT_C186376 isDefinedBy ncit.owl @default.
- NCIT_C186376 label "Oncolytic Adenovirus Expressing Interferon YSCH-01" @default.
- NCIT_C186376 subClassOf NCIT_C129821 @default.
- NCIT_C186376 subClassOf NCIT_C186376 @default.
- NCIT_C186376 subClassOf NCIT_C1908 @default.
- NCIT_C186376 subClassOf NCIT_C1909 @default.
- NCIT_C186376 subClassOf NCIT_C2139 @default.
- NCIT_C186376 subClassOf NCIT_C274 @default.
- NCIT_C186376 subClassOf NCIT_C307 @default.
- NCIT_C186376 subClassOf NCIT_C308 @default.
- NCIT_C186376 subClassOf NCIT_C717 @default.