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- NCIT_C186403 IAO_0000115 "An orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration, ivarmacitinib binds to and inhibits JAK1, thereby preventing JAK-dependent signaling. This may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation and signaling, which plays a role in neoplastic transformation, resistance to apoptosis, tumor angiogenesis, metastasis, immune evasion, and treatment resistance." @default.
- NCIT_C186403 NCIT_A5 NCIT_C186397 @default.
- NCIT_C186403 NCIT_A7 NCIT_C28493 @default.
- NCIT_C186403 NCIT_NHC0 "C186403" @default.
- NCIT_C186403 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186403 NCIT_P108 "Ivarmacitinib" @default.
- NCIT_C186403 NCIT_P208 "CL1787142" @default.
- NCIT_C186403 NCIT_P319 "K6K4B9Z5TV" @default.
- NCIT_C186403 NCIT_P322 "FDA" @default.
- NCIT_C186403 NCIT_P322 "GDC" @default.
- NCIT_C186403 NCIT_P399 "813213" @default.
- NCIT_C186403 normalizedInformationContent "100" @default.
- NCIT_C186403 referenceCount "1" @default.
- NCIT_C186403 hasExactSynonym "IVARMACITINIB" @default.
- NCIT_C186403 hasExactSynonym "Ivarmacitinib" @default.
- NCIT_C186403 hasExactSynonym "SHR 0302 Free Base" @default.
- NCIT_C186403 hasExactSynonym "SHR-0302 Free Base" @default.
- NCIT_C186403 hasExactSynonym "SHR0302 Free Base" @default.
- NCIT_C186403 inSubset NCIT_C128784 @default.
- NCIT_C186403 inSubset NCIT_C157711 @default.
- NCIT_C186403 inSubset NCIT_C157712 @default.
- NCIT_C186403 inSubset NCIT_C176424 @default.
- NCIT_C186403 inSubset NCIT_C63923 @default.
- NCIT_C186403 type Class @default.
- NCIT_C186403 isDefinedBy ncit.owl @default.
- NCIT_C186403 label "Ivarmacitinib" @default.
- NCIT_C186403 subClassOf NCIT_C129650 @default.
- NCIT_C186403 subClassOf NCIT_C129824 @default.
- NCIT_C186403 subClassOf NCIT_C129825 @default.
- NCIT_C186403 subClassOf NCIT_C1404 @default.
- NCIT_C186403 subClassOf NCIT_C172200 @default.
- NCIT_C186403 subClassOf NCIT_C186403 @default.
- NCIT_C186403 subClassOf NCIT_C1908 @default.
- NCIT_C186403 subClassOf NCIT_C1909 @default.
- NCIT_C186403 subClassOf NCIT_C1967 @default.
- NCIT_C186403 subClassOf NCIT_C2189 @default.
- NCIT_C186403 subClassOf NCIT_C274 @default.
- NCIT_C186403 subClassOf NCIT_C471 @default.