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- NCIT_C186440 IAO_0000115 "An injectable fixed-dose combination formulation composed of nivolumab, a human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1), and relatlimab-rmbw, a human IgG4 monoclonal antibody directed against the inhibitor receptor lymphocyte activation gene-3 (LAG-3), with immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration of nivolumab and relatlimab-rmbw, nivolumab binds to and blocks the activation of PD-1 by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This prevents PD-1-mediated signaling and PD-1-mediated inhibition of the immune response. Relatlimab binds to LAG-3 on tumor infiltrating lymphocytes (TILs) and prevents LAG-3 binding to major histocompatibility complex (MHC) class II. This prevents LAG-3-mediated signaling and LAG-3-mediated inhibition of the immune response. Together, blocking these two immune checkpoints re-activates the immune system, increases cytotoxic T-lymphocytes (CTLs) proliferation and activation, and leads to a reduction in tumor growth. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity. LAG-3 expression on TILs is associated with tumor-mediated immune suppression." @default.
- NCIT_C186440 NCIT_A7 NCIT_C104623 @default.
- NCIT_C186440 NCIT_A7 NCIT_C94697 @default.
- NCIT_C186440 NCIT_NHC0 "C186440" @default.
- NCIT_C186440 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186440 NCIT_P107 "Nivolumab/Relatlimab-rmbw" @default.
- NCIT_C186440 NCIT_P108 "Nivolumab/Relatlimab-rmbw" @default.
- NCIT_C186440 NCIT_P208 "CL1778976" @default.
- NCIT_C186440 NCIT_P302 "for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma." @default.
- NCIT_C186440 NCIT_P322 "CTRP" @default.
- NCIT_C186440 NCIT_P322 "GDC" @default.
- NCIT_C186440 NCIT_P399 "809169" @default.
- NCIT_C186440 NCIT_R124 NCIT_C17710 @default.
- NCIT_C186440 NCIT_R124 NCIT_C17828 @default.
- NCIT_C186440 NCIT_R124 NCIT_C18219 @default.
- NCIT_C186440 NCIT_R124 NCIT_C19986 @default.
- NCIT_C186440 NCIT_R124 NCIT_C40474 @default.
- NCIT_C186440 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C186440 referenceCount "2" @default.
- NCIT_C186440 hasExactSynonym "BMS 986213" @default.
- NCIT_C186440 hasExactSynonym "BMS-986213" @default.
- NCIT_C186440 hasExactSynonym "BMS986213" @default.
- NCIT_C186440 hasExactSynonym "Nivolumab and Relatlimab" @default.
- NCIT_C186440 hasExactSynonym "Nivolumab and Relatlimab-rmbw" @default.
- NCIT_C186440 hasExactSynonym "Nivolumab-Relatlimab-rmbw" @default.
- NCIT_C186440 hasExactSynonym "Nivolumab/Relatlimab-rmbw Injectable Formulation" @default.
- NCIT_C186440 hasExactSynonym "Nivolumab/Relatlimab-rmbw" @default.
- NCIT_C186440 hasExactSynonym "Opdivo/Relatlimab-rmbw" @default.
- NCIT_C186440 hasExactSynonym "Opdualag" @default.
- NCIT_C186440 hasExactSynonym "Relatlimab-rmbw and Nivolumab" @default.
- NCIT_C186440 hasExactSynonym "Relatlimab-rmbw-Nivolumab" @default.
- NCIT_C186440 hasExactSynonym "Relatlimab-rmbw/Nivolumab" @default.
- NCIT_C186440 inSubset NCIT_C116977 @default.
- NCIT_C186440 inSubset NCIT_C116978 @default.
- NCIT_C186440 inSubset NCIT_C128784 @default.
- NCIT_C186440 inSubset NCIT_C157711 @default.
- NCIT_C186440 inSubset NCIT_C157712 @default.
- NCIT_C186440 inSubset NCIT_C176424 @default.
- NCIT_C186440 type Class @default.
- NCIT_C186440 isDefinedBy ncit.owl @default.
- NCIT_C186440 label "Nivolumab/Relatlimab-rmbw" @default.
- NCIT_C186440 subClassOf NCIT_C124946 @default.
- NCIT_C186440 subClassOf NCIT_C128037 @default.
- NCIT_C186440 subClassOf NCIT_C129821 @default.
- NCIT_C186440 subClassOf NCIT_C129822 @default.
- NCIT_C186440 subClassOf NCIT_C134305 @default.
- NCIT_C186440 subClassOf NCIT_C141144 @default.
- NCIT_C186440 subClassOf NCIT_C143250 @default.
- NCIT_C186440 subClassOf NCIT_C163758 @default.
- NCIT_C186440 subClassOf NCIT_C186440 @default.
- NCIT_C186440 subClassOf NCIT_C1908 @default.
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- NCIT_C186440 subClassOf NCIT_C200483 @default.
- NCIT_C186440 subClassOf NCIT_C20401 @default.
- NCIT_C186440 subClassOf NCIT_C274 @default.
- NCIT_C186440 subClassOf NCIT_C307 @default.
- NCIT_C186440 subClassOf NCIT_C308 @default.