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- NCIT_C186590 IAO_0000115 "A combination agent composed of the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class of anesthetics, and the synthetic form of the naturally occurring sympathomimetic amine epinephrine, with local vasoconstricting and anesthetic activities. Upon local administration of lidocaine hydrochloride/epinephrine by injection, epinephrine binds to and stimulates vascular alpha-adrenergic receptors, thereby causing vasoconstriction. Lidocaine interacts with voltage-gated sodium (Na+) channels in the nerve cell membranes and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. By administering epinephrine, lidocaine's potential to disperse into the surrounding tissue is reduced, thereby increasing its local efficacy, and enhancing and prolonging the anesthetic effect." @default.
- NCIT_C186590 NCIT_NHC0 "C186590" @default.
- NCIT_C186590 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186590 NCIT_P108 "Lidocaine Hydrochloride/Epinephrine" @default.
- NCIT_C186590 NCIT_P208 "CL1778851" @default.
- NCIT_C186590 normalizedInformationContent "100" @default.
- NCIT_C186590 referenceCount "1" @default.
- NCIT_C186590 hasExactSynonym "Lidocaine HCI and Epinephrine" @default.
- NCIT_C186590 hasExactSynonym "Lidocaine Hydrochloride/Epinephrine" @default.
- NCIT_C186590 hasExactSynonym "Lidocaine/Epinephrine" @default.
- NCIT_C186590 hasExactSynonym "Xylocaine-Epinephrine" @default.
- NCIT_C186590 hasExactSynonym "Xylocaine/Epinephrine" @default.
- NCIT_C186590 type Class @default.
- NCIT_C186590 isDefinedBy ncit.owl @default.
- NCIT_C186590 label "Lidocaine Hydrochloride/Epinephrine" @default.
- NCIT_C186590 subClassOf NCIT_C186590 @default.
- NCIT_C186590 subClassOf NCIT_C1908 @default.
- NCIT_C186590 subClassOf NCIT_C1909 @default.
- NCIT_C186590 subClassOf NCIT_C245 @default.
- NCIT_C186590 subClassOf NCIT_C78272 @default.