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- NCIT_C186653 IAO_0000115 "An orally bioavailable selective inhibitor of the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, RET inhibitor HS-10365 selectively binds to and inhibits the activity of RET. This results in an inhibition of cell growth of tumors that exhibit increased RET activity. RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers." @default.
- NCIT_C186653 NCIT_A7 NCIT_C18539 @default.
- NCIT_C186653 NCIT_NHC0 "C186653" @default.
- NCIT_C186653 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186653 NCIT_P108 "RET Inhibitor HS-10365" @default.
- NCIT_C186653 NCIT_P208 "CL1778791" @default.
- NCIT_C186653 NCIT_P322 "GDC" @default.
- NCIT_C186653 NCIT_P399 "809153" @default.
- NCIT_C186653 normalizedInformationContent "100" @default.
- NCIT_C186653 referenceCount "1" @default.
- NCIT_C186653 hasExactSynonym "HS 10365" @default.
- NCIT_C186653 hasExactSynonym "HS-10365" @default.
- NCIT_C186653 hasExactSynonym "HS10365" @default.
- NCIT_C186653 hasExactSynonym "RET Inhibitor HS-10365" @default.
- NCIT_C186653 inSubset NCIT_C128784 @default.
- NCIT_C186653 inSubset NCIT_C157711 @default.
- NCIT_C186653 inSubset NCIT_C157712 @default.
- NCIT_C186653 inSubset NCIT_C176424 @default.
- NCIT_C186653 type Class @default.
- NCIT_C186653 isDefinedBy ncit.owl @default.
- NCIT_C186653 label "RET Inhibitor HS-10365" @default.
- NCIT_C186653 subClassOf NCIT_C129824 @default.
- NCIT_C186653 subClassOf NCIT_C129825 @default.
- NCIT_C186653 subClassOf NCIT_C1404 @default.
- NCIT_C186653 subClassOf NCIT_C159438 @default.
- NCIT_C186653 subClassOf NCIT_C163758 @default.
- NCIT_C186653 subClassOf NCIT_C186653 @default.
- NCIT_C186653 subClassOf NCIT_C1908 @default.
- NCIT_C186653 subClassOf NCIT_C1909 @default.
- NCIT_C186653 subClassOf NCIT_C1967 @default.
- NCIT_C186653 subClassOf NCIT_C2189 @default.
- NCIT_C186653 subClassOf NCIT_C274 @default.
- NCIT_C186653 subClassOf NCIT_C471 @default.