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- NCIT_C186656 IAO_0000115 "A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Upon administration, tubulin polymerization inhibitor AB8939 binds to tubulin and prevents its polymerization in tumor blood vessel endothelial cells and tumor cells. This blocks the formation of the mitotic spindle and leads to cell cycle arrest at the G2/M phase. As a result, this agent disrupts the tumor vasculature and tumor blood flow, deprives tumor cells of nutrients and induces tumor cell apoptosis. In addition, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. Additionally, unlike similar agents of this class, AB8939 may be able to circumvent some drug resistance mechanisms." @default.
- NCIT_C186656 NCIT_A7 NCIT_C17219 @default.
- NCIT_C186656 NCIT_NHC0 "C186656" @default.
- NCIT_C186656 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186656 NCIT_P107 "Tubulin Polymerization Inhibitor AB8939" @default.
- NCIT_C186656 NCIT_P108 "Tubulin Polymerization Inhibitor AB8939" @default.
- NCIT_C186656 NCIT_P208 "CL1778794" @default.
- NCIT_C186656 NCIT_P319 "REU6L9A46J" @default.
- NCIT_C186656 NCIT_P322 "CTRP" @default.
- NCIT_C186656 NCIT_P322 "FDA" @default.
- NCIT_C186656 NCIT_P322 "GDC" @default.
- NCIT_C186656 NCIT_P399 "809160" @default.
- NCIT_C186656 NCIT_R124 NCIT_C17828 @default.
- NCIT_C186656 NCIT_R124 NCIT_C20480 @default.
- NCIT_C186656 NCIT_R124 NCIT_C40795 @default.
- NCIT_C186656 NCIT_R124 NCIT_C40798 @default.
- NCIT_C186656 normalizedInformationContent "100" @default.
- NCIT_C186656 referenceCount "1" @default.
- NCIT_C186656 hasExactSynonym "AB 8939" @default.
- NCIT_C186656 hasExactSynonym "AB-8939" @default.
- NCIT_C186656 hasExactSynonym "AB8939" @default.
- NCIT_C186656 hasExactSynonym "Tubulin Polymerization Inhibitor AB8939" @default.
- NCIT_C186656 inSubset NCIT_C116977 @default.
- NCIT_C186656 inSubset NCIT_C116978 @default.
- NCIT_C186656 inSubset NCIT_C128784 @default.
- NCIT_C186656 inSubset NCIT_C157711 @default.
- NCIT_C186656 inSubset NCIT_C157712 @default.
- NCIT_C186656 inSubset NCIT_C176424 @default.
- NCIT_C186656 inSubset NCIT_C63923 @default.
- NCIT_C186656 type Class @default.
- NCIT_C186656 isDefinedBy ncit.owl @default.
- NCIT_C186656 label "Tubulin Polymerization Inhibitor AB8939" @default.
- NCIT_C186656 subClassOf NCIT_C186656 @default.
- NCIT_C186656 subClassOf NCIT_C186664 @default.
- NCIT_C186656 subClassOf NCIT_C1908 @default.
- NCIT_C186656 subClassOf NCIT_C1909 @default.
- NCIT_C186656 subClassOf NCIT_C25974 @default.
- NCIT_C186656 subClassOf NCIT_C273 @default.
- NCIT_C186656 subClassOf NCIT_C274 @default.