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- NCIT_C186665 IAO_0000115 "A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness." @default.
- NCIT_C186665 NCIT_NHC0 "C186665" @default.
- NCIT_C186665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186665 NCIT_P108 "Anti-5T4 CAR-NK Cells" @default.
- NCIT_C186665 NCIT_P208 "CL1779166" @default.
- NCIT_C186665 NCIT_P399 "809140" @default.
- NCIT_C186665 normalizedInformationContent "100" @default.
- NCIT_C186665 referenceCount "1" @default.
- NCIT_C186665 hasExactSynonym "Anti-5T4 CAR Natural Killer Cells" @default.
- NCIT_C186665 hasExactSynonym "Anti-5T4 CAR-NK Cells" @default.
- NCIT_C186665 hasExactSynonym "Anti-5T4 CAR-NKs" @default.
- NCIT_C186665 hasExactSynonym "Anti-5T4 CAR-redirected Natural Killer Cells" @default.
- NCIT_C186665 inSubset NCIT_C128784 @default.
- NCIT_C186665 inSubset NCIT_C176424 @default.
- NCIT_C186665 type Class @default.
- NCIT_C186665 isDefinedBy ncit.owl @default.
- NCIT_C186665 label "Anti-5T4 CAR-NK Cells" @default.
- NCIT_C186665 subClassOf NCIT_C129820 @default.
- NCIT_C186665 subClassOf NCIT_C129821 @default.
- NCIT_C186665 subClassOf NCIT_C129826 @default.
- NCIT_C186665 subClassOf NCIT_C142078 @default.
- NCIT_C186665 subClassOf NCIT_C186665 @default.
- NCIT_C186665 subClassOf NCIT_C1908 @default.
- NCIT_C186665 subClassOf NCIT_C1909 @default.
- NCIT_C186665 subClassOf NCIT_C201545 @default.
- NCIT_C186665 subClassOf NCIT_C274 @default.
- NCIT_C186665 subClassOf NCIT_C28676 @default.
- NCIT_C186665 subClassOf NCIT_C307 @default.
- NCIT_C186665 subClassOf NCIT_C308 @default.