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- NCIT_C186670 IAO_0000115 "A dual-targeted antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed against the epidermal growth factor receptor (EGFR; HER1; ErbB1) and the epidermal growth factor receptor 3 (HER3; ErbB3) and conjugated to an as of yet not elucidated cytotoxic payload, with potential antineoplastic activity. Upon administration of anti-EGFR/anti-HER3 ADC BL-B01D1, the monoclonal antibody moieties simultaneously target and bind to EGFR and HER3 expressed on cancer cells. Following receptor internalization, the cytotoxic moiety is released and kills EGFR/HER3-expressing tumor cells through an as of yet unknown mechanism of action (MoA). EGFR and HER3, both upregulated and/or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation. Simultaneously targeting both EGFR and HER3 may enhance the anti-tumor activity of BL-B01D1." @default.
- NCIT_C186670 NCIT_A7 NCIT_C17068 @default.
- NCIT_C186670 NCIT_A7 NCIT_C18490 @default.
- NCIT_C186670 NCIT_NHC0 "C186670" @default.
- NCIT_C186670 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C186670 NCIT_P108 "Anti-EGFR/anti-HER3 Antibody-drug Conjugate BL-B01D1" @default.
- NCIT_C186670 NCIT_P208 "CL1779171" @default.
- NCIT_C186670 NCIT_P322 "GDC" @default.
- NCIT_C186670 NCIT_P399 "809141" @default.
- NCIT_C186670 normalizedInformationContent "100" @default.
- NCIT_C186670 referenceCount "1" @default.
- NCIT_C186670 hasExactSynonym "ADC BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "Anti-EGFR/HER3 ADC BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "Anti-EGFR/anti-HER3 ADC BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "Anti-EGFR/anti-HER3 Antibody-drug Conjugate BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "BL B01D1" @default.
- NCIT_C186670 hasExactSynonym "BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "BLB01D1" @default.
- NCIT_C186670 hasExactSynonym "Dual Antibody ADC BL-B01D1" @default.
- NCIT_C186670 hasExactSynonym "Dual Target ADC BL-B01D1" @default.
- NCIT_C186670 inSubset NCIT_C128784 @default.
- NCIT_C186670 inSubset NCIT_C157711 @default.
- NCIT_C186670 inSubset NCIT_C157712 @default.
- NCIT_C186670 inSubset NCIT_C176424 @default.
- NCIT_C186670 type Class @default.
- NCIT_C186670 isDefinedBy ncit.owl @default.
- NCIT_C186670 label "Anti-EGFR/anti-HER3 Antibody-drug Conjugate BL-B01D1" @default.
- NCIT_C186670 subClassOf NCIT_C129821 @default.
- NCIT_C186670 subClassOf NCIT_C129823 @default.
- NCIT_C186670 subClassOf NCIT_C1512 @default.
- NCIT_C186670 subClassOf NCIT_C163758 @default.
- NCIT_C186670 subClassOf NCIT_C163952 @default.
- NCIT_C186670 subClassOf NCIT_C186670 @default.
- NCIT_C186670 subClassOf NCIT_C1908 @default.
- NCIT_C186670 subClassOf NCIT_C1909 @default.
- NCIT_C186670 subClassOf NCIT_C199383 @default.
- NCIT_C186670 subClassOf NCIT_C199385 @default.
- NCIT_C186670 subClassOf NCIT_C201551 @default.
- NCIT_C186670 subClassOf NCIT_C274 @default.
- NCIT_C186670 subClassOf NCIT_C307 @default.
- NCIT_C186670 subClassOf NCIT_C308 @default.