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- NCIT_C1867 IAO_0000115 "A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in the inhibition of cell division and cellular proliferation. As it represents a poor substrate for P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1 and BCRP." @default.
- NCIT_C1867 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1867 NCIT_NHC0 "C1867" @default.
- NCIT_C1867 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1867 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1867 NCIT_P108 "Ortataxel" @default.
- NCIT_C1867 NCIT_P207 "C1527103" @default.
- NCIT_C1867 NCIT_P210 "186348-23-2" @default.
- NCIT_C1867 NCIT_P319 "8H61Y4E29N" @default.
- NCIT_C1867 NCIT_P322 "FDA" @default.
- NCIT_C1867 NCIT_P322 "GDC" @default.
- NCIT_C1867 NCIT_P325 "A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called taxanes." @default.
- NCIT_C1867 NCIT_P329 "38635" @default.
- NCIT_C1867 NCIT_P330 "38635" @default.
- NCIT_C1867 NCIT_P366 "Orataxel" @default.
- NCIT_C1867 NCIT_P375 "Ortataxel" @default.
- NCIT_C1867 NCIT_P399 "38635" @default.
- NCIT_C1867 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1867 NCIT_R124 NCIT_C20480 @default.
- NCIT_C1867 NCIT_R124 NCIT_C40795 @default.
- NCIT_C1867 NCIT_R124 NCIT_C40798 @default.
- NCIT_C1867 normalizedInformationContent "100" @default.
- NCIT_C1867 referenceCount "1" @default.
- NCIT_C1867 hasExactSynonym "(3aS,4R,5E,7R,8aS,9S,10aR,12aS,12bR,13S,13aS)-7,12a-Bis(acetyloxy)-13-(benzoyloxy)-9-hydroxy-5,8a,14,14-tetramethyl-2,8-dioxo-3a,4,7,8,8a,9,10,10a,12,12a,12b,13-dodecahydro-6,13a-methano-13aH-oxeto(2',3':5',6')benzo(1',2':4,5)cyclodeca(1,2-d)-1,3-dioxol-4-yl(2R,3S)-3-(((1,1-dimethylethoxy)carbonyl)amino)-2-hydroxy-5-methylhexanoate" @default.
- NCIT_C1867 hasExactSynonym "BAY 59-8862" @default.
- NCIT_C1867 hasExactSynonym "BAY59-8862" @default.
- NCIT_C1867 hasExactSynonym "Bay 59-8862" @default.
- NCIT_C1867 hasExactSynonym "IDN5109" @default.
- NCIT_C1867 hasExactSynonym "ORTATAXEL" @default.
- NCIT_C1867 hasExactSynonym "Ortataxel" @default.
- NCIT_C1867 hasExactSynonym "SB-T-101131" @default.
- NCIT_C1867 inSubset NCIT_C128784 @default.
- NCIT_C1867 inSubset NCIT_C157711 @default.
- NCIT_C1867 inSubset NCIT_C157712 @default.
- NCIT_C1867 inSubset NCIT_C176424 @default.
- NCIT_C1867 inSubset NCIT_C177537 @default.
- NCIT_C1867 inSubset NCIT_C63923 @default.
- NCIT_C1867 type Class @default.
- NCIT_C1867 isDefinedBy ncit.owl @default.
- NCIT_C1867 label "Ortataxel" @default.
- NCIT_C1867 subClassOf NCIT_C1490 @default.
- NCIT_C1867 subClassOf NCIT_C186664 @default.
- NCIT_C1867 subClassOf NCIT_C1867 @default.
- NCIT_C1867 subClassOf NCIT_C1908 @default.
- NCIT_C1867 subClassOf NCIT_C1909 @default.
- NCIT_C1867 subClassOf NCIT_C1913 @default.
- NCIT_C1867 subClassOf NCIT_C25974 @default.
- NCIT_C1867 subClassOf NCIT_C273 @default.
- NCIT_C1867 subClassOf NCIT_C274 @default.
- NCIT_C1867 subClassOf NCIT_C552 @default.
- NCIT_C1867 subClassOf NCIT_C616 @default.
- NCIT_C1867 subClassOf NCIT_C67437 @default.
- NCIT_C1867 subClassOf NCIT_C718 @default.
- NCIT_C1867 subClassOf NCIT_C860 @default.