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- NCIT_C186746 IAO_0000115 "A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the radioisotope indium In 111, with potential use as an imaging agent. Upon administration, the monoclonal antibody moiety of indium In 111-DOTA-daratumumab specifically targets and binds to cell surface antigen CD38. Upon binding and gamma scintigraphy, CD38-expressing tumor cells can be visualized, and the binding and biodistribution of daratumumab can be assessed. CD38, a cell surface glycoprotein, is expressed on various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells." @default.
- NCIT_C186746 NCIT_A7 NCIT_C84323 @default.
- NCIT_C186746 NCIT_NHC0 "C186746" @default.
- NCIT_C186746 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C186746 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C186746 NCIT_P107 "Indium In 111-DOTA-Daratumumab" @default.
- NCIT_C186746 NCIT_P108 "Indium In 111-DOTA-Daratumumab" @default.
- NCIT_C186746 NCIT_P208 "CL1779112" @default.
- NCIT_C186746 NCIT_P322 "CTRP" @default.
- NCIT_C186746 NCIT_P399 "809894" @default.
- NCIT_C186746 normalizedInformationContent "100" @default.
- NCIT_C186746 referenceCount "1" @default.
- NCIT_C186746 hasExactSynonym "111In-DOTA-Daratumumab" @default.
- NCIT_C186746 hasExactSynonym "Indium In 111-DOTA-Daratumumab" @default.
- NCIT_C186746 hasExactSynonym "[111In]-DOTA-Daratumumab" @default.
- NCIT_C186746 inSubset NCIT_C116977 @default.
- NCIT_C186746 inSubset NCIT_C116978 @default.
- NCIT_C186746 inSubset NCIT_C176424 @default.
- NCIT_C186746 type Class @default.
- NCIT_C186746 isDefinedBy ncit.owl @default.
- NCIT_C186746 label "Indium In 111-DOTA-Daratumumab" @default.
- NCIT_C186746 subClassOf NCIT_C1446 @default.
- NCIT_C186746 subClassOf NCIT_C1511 @default.
- NCIT_C186746 subClassOf NCIT_C1512 @default.
- NCIT_C186746 subClassOf NCIT_C186746 @default.
- NCIT_C186746 subClassOf NCIT_C1908 @default.
- NCIT_C186746 subClassOf NCIT_C1909 @default.
- NCIT_C186746 subClassOf NCIT_C2124 @default.
- NCIT_C186746 subClassOf NCIT_C307 @default.
- NCIT_C186746 subClassOf NCIT_C308 @default.