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- NCIT_C187021 IAO_0000115 "A conjugate composed of folic acid analogs and exatecans covalently bound by linkers to the ultrasmall silica-based nanoparticle carrier C'Dot, with potential antineoplastic activity. Upon administration of FR-alpha-targeting ultrasmall silica nanoparticle-drug conjugate ELU001, the folic acid analogs target and bind to the human folate receptor 1 (FOLR1; FR-alpha) on FR-alpha-expressing tumor cells. Following internalization of ELU001, the camptothecin analog exatecan is released via proteolytic cleavage of the linker. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. FR-alpha is a high-affinity folate-binding protein and a member of the folate receptor family; it is overexpressed in various cancer cell types." @default.
- NCIT_C187021 NCIT_A7 NCIT_C16516 @default.
- NCIT_C187021 NCIT_NHC0 "C187021" @default.
- NCIT_C187021 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187021 NCIT_P107 "Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001" @default.
- NCIT_C187021 NCIT_P108 "Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001" @default.
- NCIT_C187021 NCIT_P208 "CL1779263" @default.
- NCIT_C187021 NCIT_P322 "CTRP" @default.
- NCIT_C187021 NCIT_P322 "GDC" @default.
- NCIT_C187021 NCIT_P399 "809893" @default.
- NCIT_C187021 normalizedInformationContent "100" @default.
- NCIT_C187021 referenceCount "1" @default.
- NCIT_C187021 hasExactSynonym "EC112002" @default.
- NCIT_C187021 hasExactSynonym "ELU 001" @default.
- NCIT_C187021 hasExactSynonym "ELU-001" @default.
- NCIT_C187021 hasExactSynonym "ELU001" @default.
- NCIT_C187021 hasExactSynonym "FA-CDC ELU001" @default.
- NCIT_C187021 hasExactSynonym "FR-alpha-targeting CDC ELU001" @default.
- NCIT_C187021 hasExactSynonym "FR-alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001" @default.
- NCIT_C187021 hasExactSynonym "Folate-receptor Alpha-targeting C'Dot-drug Conjugate ELU001" @default.
- NCIT_C187021 hasExactSynonym "Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001" @default.
- NCIT_C187021 hasExactSynonym "Folic-acid Functionalized C'Dot-drug-conjugate ELU001" @default.
- NCIT_C187021 inSubset NCIT_C116977 @default.
- NCIT_C187021 inSubset NCIT_C116978 @default.
- NCIT_C187021 inSubset NCIT_C128784 @default.
- NCIT_C187021 inSubset NCIT_C157711 @default.
- NCIT_C187021 inSubset NCIT_C157712 @default.
- NCIT_C187021 inSubset NCIT_C176424 @default.
- NCIT_C187021 type Class @default.
- NCIT_C187021 isDefinedBy ncit.owl @default.
- NCIT_C187021 label "Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001" @default.
- NCIT_C187021 subClassOf NCIT_C129824 @default.
- NCIT_C187021 subClassOf NCIT_C129825 @default.
- NCIT_C187021 subClassOf NCIT_C163758 @default.
- NCIT_C187021 subClassOf NCIT_C1748 @default.
- NCIT_C187021 subClassOf NCIT_C187021 @default.
- NCIT_C187021 subClassOf NCIT_C1904 @default.
- NCIT_C187021 subClassOf NCIT_C1908 @default.
- NCIT_C187021 subClassOf NCIT_C1909 @default.
- NCIT_C187021 subClassOf NCIT_C200114 @default.
- NCIT_C187021 subClassOf NCIT_C2189 @default.
- NCIT_C187021 subClassOf NCIT_C274 @default.
- NCIT_C187021 subClassOf NCIT_C2843 @default.
- NCIT_C187021 subClassOf NCIT_C471 @default.