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- NCIT_C187029 IAO_0000115 "An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily stem cell memory T-cells (Tscm) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the C-terminal subunit of the tumor-associated antigen (TAA) mucin-1 (MUC1-C) and gene-edited to knockout both the T-cell receptor (TCR) and major histocompatibility complex (MHC) class I proteins, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic MUC1-C-specific CAR-T cells P-MUC1C-ALLO1 specifically recognize and induce selective toxicity in MUC1-C-expressing tumor cells. MUC1, a glycoprotein normally expressed on epithelial cells and overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. The proteolytic cleavage of MUC1 in the tumor microenvironment (TME) leads to the overexpression of MUC1-C in the TME." @default.
- NCIT_C187029 NCIT_A7 NCIT_C2407 @default.
- NCIT_C187029 NCIT_NHC0 "C187029" @default.
- NCIT_C187029 NCIT_P106 "Cell" @default.
- NCIT_C187029 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187029 NCIT_P108 "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1" @default.
- NCIT_C187029 NCIT_P208 "CL1779239" @default.
- NCIT_C187029 NCIT_P322 "GDC" @default.
- NCIT_C187029 NCIT_P399 "809278" @default.
- NCIT_C187029 normalizedInformationContent "100" @default.
- NCIT_C187029 referenceCount "1" @default.
- NCIT_C187029 hasExactSynonym "Allogeneic Anti-MUC1-C CAR T Cells P-MUC1C-ALLO1" @default.
- NCIT_C187029 hasExactSynonym "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1" @default.
- NCIT_C187029 hasExactSynonym "P-MUC1C-ALLO 1" @default.
- NCIT_C187029 hasExactSynonym "P-MUC1C-ALLO-1" @default.
- NCIT_C187029 hasExactSynonym "P-MUC1C-ALLO1 CAR-T Cells" @default.
- NCIT_C187029 hasExactSynonym "P-MUC1C-ALLO1" @default.
- NCIT_C187029 inSubset NCIT_C128784 @default.
- NCIT_C187029 inSubset NCIT_C157711 @default.
- NCIT_C187029 inSubset NCIT_C157712 @default.
- NCIT_C187029 inSubset NCIT_C176424 @default.
- NCIT_C187029 type Class @default.
- NCIT_C187029 isDefinedBy ncit.owl @default.
- NCIT_C187029 label "Allogeneic MUC1-C-specific CAR-T Cells P-MUC1C-ALLO1" @default.
- NCIT_C187029 subClassOf NCIT_C129820 @default.
- NCIT_C187029 subClassOf NCIT_C129821 @default.
- NCIT_C187029 subClassOf NCIT_C129826 @default.
- NCIT_C187029 subClassOf NCIT_C137999 @default.
- NCIT_C187029 subClassOf NCIT_C142078 @default.
- NCIT_C187029 subClassOf NCIT_C154231 @default.
- NCIT_C187029 subClassOf NCIT_C187029 @default.
- NCIT_C187029 subClassOf NCIT_C1908 @default.
- NCIT_C187029 subClassOf NCIT_C1909 @default.
- NCIT_C187029 subClassOf NCIT_C1962 @default.
- NCIT_C187029 subClassOf NCIT_C200765 @default.
- NCIT_C187029 subClassOf NCIT_C274 @default.
- NCIT_C187029 subClassOf NCIT_C28676 @default.
- NCIT_C187029 subClassOf NCIT_C307 @default.
- NCIT_C187029 subClassOf NCIT_C308 @default.