Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187034> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- NCIT_C187034 IAO_0000115 "An orally bioavailable, third-generation inhibitor of the receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, ALK inhibitor SY-3505 binds to and inhibits ALK wild-type tyrosine kinase and numerous ALK mutations, including acquired resistance mutations. Inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types." @default.
- NCIT_C187034 NCIT_A7 NCIT_C27032 @default.
- NCIT_C187034 NCIT_NHC0 "C187034" @default.
- NCIT_C187034 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187034 NCIT_P108 "ALK Inhibitor SY-3505" @default.
- NCIT_C187034 NCIT_P208 "CL1779244" @default.
- NCIT_C187034 NCIT_P322 "GDC" @default.
- NCIT_C187034 NCIT_P399 "809333" @default.
- NCIT_C187034 normalizedInformationContent "100" @default.
- NCIT_C187034 referenceCount "1" @default.
- NCIT_C187034 hasExactSynonym "ALK Inhibitor SY-3505" @default.
- NCIT_C187034 hasExactSynonym "ALK TKI SY-3505" @default.
- NCIT_C187034 hasExactSynonym "CT 3505" @default.
- NCIT_C187034 hasExactSynonym "CT-3505" @default.
- NCIT_C187034 hasExactSynonym "CT3505" @default.
- NCIT_C187034 hasExactSynonym "SY 3505" @default.
- NCIT_C187034 hasExactSynonym "SY-3505" @default.
- NCIT_C187034 hasExactSynonym "SY3505" @default.
- NCIT_C187034 inSubset NCIT_C128784 @default.
- NCIT_C187034 inSubset NCIT_C157711 @default.
- NCIT_C187034 inSubset NCIT_C157712 @default.
- NCIT_C187034 inSubset NCIT_C176424 @default.
- NCIT_C187034 type Class @default.
- NCIT_C187034 isDefinedBy ncit.owl @default.
- NCIT_C187034 label "ALK Inhibitor SY-3505" @default.
- NCIT_C187034 subClassOf NCIT_C129824 @default.
- NCIT_C187034 subClassOf NCIT_C129825 @default.
- NCIT_C187034 subClassOf NCIT_C1404 @default.
- NCIT_C187034 subClassOf NCIT_C141136 @default.
- NCIT_C187034 subClassOf NCIT_C163758 @default.
- NCIT_C187034 subClassOf NCIT_C187034 @default.
- NCIT_C187034 subClassOf NCIT_C1908 @default.
- NCIT_C187034 subClassOf NCIT_C1909 @default.
- NCIT_C187034 subClassOf NCIT_C1967 @default.
- NCIT_C187034 subClassOf NCIT_C2189 @default.
- NCIT_C187034 subClassOf NCIT_C274 @default.
- NCIT_C187034 subClassOf NCIT_C471 @default.