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- NCIT_C187035 IAO_0000115 "An oncolytic herpes simplex virus type 1 (oHSV-1) genetically engineered to express the human immunostimulating cytokine interleukin (IL)-12 and a complex of the immunostimulating cytokine IL-15 and its receptor alpha unit (IL-15Ra), with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, oHSV-1 expressing IL-12 and IL-15/IL-15Ra VG2025 infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. In addition, oHSV-1 expressing IL-12 and IL-15/IL-15Ra VG2025 promotes the secretion of IL-12 and IL-15/IL-15Ra complex by the tumor cells locally in the tumor microenvironment (TME). IL-12 promotes the activation of natural killer (NK) cells, which induces both the secretion of interferon-gamma and a CTL response against the tumor cells. IL-15 stimulates the proliferation of NK cells, CTLs and memory T-cells, which induces an anti-tumor immune response. IL-15Ra complexed with IL-15 increases IL-15 signaling and IL-15 half-life upon expression. These actions of the cytokines may increase tumor cell killing and decrease tumor cell proliferation." @default.
- NCIT_C187035 NCIT_NHC0 "C187035" @default.
- NCIT_C187035 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187035 NCIT_P108 "Oncolytic HSV-1 Expressing IL-12 and IL-15/IL-15-receptor Alpha VG2025" @default.
- NCIT_C187035 NCIT_P208 "CL1779245" @default.
- NCIT_C187035 NCIT_P322 "GDC" @default.
- NCIT_C187035 NCIT_P399 "809334" @default.
- NCIT_C187035 normalizedInformationContent "100" @default.
- NCIT_C187035 referenceCount "1" @default.
- NCIT_C187035 hasExactSynonym "Oncolytic HSV-1 Expressing IL-12 and IL-15/IL-15-receptor Alpha VG2025" @default.
- NCIT_C187035 hasExactSynonym "VG 2025" @default.
- NCIT_C187035 hasExactSynonym "VG-2025" @default.
- NCIT_C187035 hasExactSynonym "VG2025" @default.
- NCIT_C187035 hasExactSynonym "oHSV-1 Expressing IL-12 and IL-15/IL-15Ra VG2025" @default.
- NCIT_C187035 inSubset NCIT_C128784 @default.
- NCIT_C187035 inSubset NCIT_C157711 @default.
- NCIT_C187035 inSubset NCIT_C157712 @default.
- NCIT_C187035 inSubset NCIT_C176424 @default.
- NCIT_C187035 type Class @default.
- NCIT_C187035 isDefinedBy ncit.owl @default.
- NCIT_C187035 label "Oncolytic HSV-1 Expressing IL-12 and IL-15/IL-15-receptor Alpha VG2025" @default.
- NCIT_C187035 subClassOf NCIT_C129821 @default.
- NCIT_C187035 subClassOf NCIT_C187035 @default.
- NCIT_C187035 subClassOf NCIT_C1908 @default.
- NCIT_C187035 subClassOf NCIT_C1909 @default.
- NCIT_C187035 subClassOf NCIT_C274 @default.
- NCIT_C187035 subClassOf NCIT_C307 @default.
- NCIT_C187035 subClassOf NCIT_C717 @default.