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- NCIT_C187044 IAO_0000115 "The dihydrochloride salt form of NRC-2694, an orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C187044 NCIT_A6 NCIT_C187045 @default.
- NCIT_C187044 NCIT_A7 NCIT_C17068 @default.
- NCIT_C187044 NCIT_NHC0 "C187044" @default.
- NCIT_C187044 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187044 NCIT_P108 "EGFR Inhibitor NRC-2694 Dihydrochloride" @default.
- NCIT_C187044 NCIT_P208 "CL1779200" @default.
- NCIT_C187044 NCIT_P210 "1172627-00-7" @default.
- NCIT_C187044 NCIT_P319 "JRT6MBD7C2" @default.
- NCIT_C187044 NCIT_P322 "FDA" @default.
- NCIT_C187044 NCIT_P322 "GDC" @default.
- NCIT_C187044 normalizedInformationContent "100" @default.
- NCIT_C187044 referenceCount "1" @default.
- NCIT_C187044 hasExactSynonym "EGFR Inhibitor NRC-2694 Dihydrochloride" @default.
- NCIT_C187044 hasExactSynonym "NRC-2694 DIHYDROCHLORIDE" @default.
- NCIT_C187044 hasExactSynonym "NRC-2694-B" @default.
- NCIT_C187044 hasExactSynonym "NRC-2694B" @default.
- NCIT_C187044 inSubset NCIT_C128784 @default.
- NCIT_C187044 inSubset NCIT_C157711 @default.
- NCIT_C187044 inSubset NCIT_C157712 @default.
- NCIT_C187044 inSubset NCIT_C176424 @default.
- NCIT_C187044 inSubset NCIT_C63923 @default.
- NCIT_C187044 type Class @default.
- NCIT_C187044 isDefinedBy ncit.owl @default.
- NCIT_C187044 label "EGFR Inhibitor NRC-2694 Dihydrochloride" @default.
- NCIT_C187044 subClassOf NCIT_C129824 @default.
- NCIT_C187044 subClassOf NCIT_C129825 @default.
- NCIT_C187044 subClassOf NCIT_C1404 @default.
- NCIT_C187044 subClassOf NCIT_C163758 @default.
- NCIT_C187044 subClassOf NCIT_C163952 @default.
- NCIT_C187044 subClassOf NCIT_C187044 @default.
- NCIT_C187044 subClassOf NCIT_C1908 @default.
- NCIT_C187044 subClassOf NCIT_C1909 @default.
- NCIT_C187044 subClassOf NCIT_C1967 @default.
- NCIT_C187044 subClassOf NCIT_C2167 @default.
- NCIT_C187044 subClassOf NCIT_C2189 @default.
- NCIT_C187044 subClassOf NCIT_C274 @default.
- NCIT_C187044 subClassOf NCIT_C471 @default.