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- NCIT_C187046 IAO_0000115 "An orally bioavailable, central nervous system (CNS)-penetrating, irreversible covalent inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon oral administration, BTK inhibitor GB5121 selectively targets, irriversibly binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies. It plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival. GB5121 is able to penetrate the blood-brain-barrier (BBB) and may thereby treat BTK-driven CNS tumors and metastasis." @default.
- NCIT_C187046 NCIT_A7 NCIT_C75017 @default.
- NCIT_C187046 NCIT_NHC0 "C187046" @default.
- NCIT_C187046 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187046 NCIT_P107 "BTK Inhibitor GB5121" @default.
- NCIT_C187046 NCIT_P108 "BTK Inhibitor GB5121" @default.
- NCIT_C187046 NCIT_P208 "CL1779202" @default.
- NCIT_C187046 NCIT_P322 "CTRP" @default.
- NCIT_C187046 NCIT_P322 "GDC" @default.
- NCIT_C187046 NCIT_P399 "809271" @default.
- NCIT_C187046 normalizedInformationContent "100" @default.
- NCIT_C187046 referenceCount "1" @default.
- NCIT_C187046 hasExactSynonym "BTK Inhibitor GB5121" @default.
- NCIT_C187046 hasExactSynonym "GB 5121" @default.
- NCIT_C187046 hasExactSynonym "GB-5121" @default.
- NCIT_C187046 inSubset NCIT_C116977 @default.
- NCIT_C187046 inSubset NCIT_C116978 @default.
- NCIT_C187046 inSubset NCIT_C128784 @default.
- NCIT_C187046 inSubset NCIT_C157711 @default.
- NCIT_C187046 inSubset NCIT_C157712 @default.
- NCIT_C187046 inSubset NCIT_C176424 @default.
- NCIT_C187046 type Class @default.
- NCIT_C187046 isDefinedBy ncit.owl @default.
- NCIT_C187046 label "BTK Inhibitor GB5121" @default.
- NCIT_C187046 subClassOf NCIT_C124801 @default.
- NCIT_C187046 subClassOf NCIT_C129824 @default.
- NCIT_C187046 subClassOf NCIT_C129825 @default.
- NCIT_C187046 subClassOf NCIT_C1404 @default.
- NCIT_C187046 subClassOf NCIT_C163758 @default.
- NCIT_C187046 subClassOf NCIT_C163774 @default.
- NCIT_C187046 subClassOf NCIT_C187046 @default.
- NCIT_C187046 subClassOf NCIT_C1908 @default.
- NCIT_C187046 subClassOf NCIT_C1909 @default.
- NCIT_C187046 subClassOf NCIT_C1967 @default.
- NCIT_C187046 subClassOf NCIT_C2189 @default.
- NCIT_C187046 subClassOf NCIT_C274 @default.
- NCIT_C187046 subClassOf NCIT_C471 @default.