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- NCIT_C187050 IAO_0000115 "A preparation of autologous tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. The TILs are isolated from an autologous tumor sample and engineered to express mbIL-12. Upon infusion of the autologous mbIL-12-expressing TILs GT202 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells." @default.
- NCIT_C187050 NCIT_NHC0 "C187050" @default.
- NCIT_C187050 NCIT_P106 "Cell" @default.
- NCIT_C187050 NCIT_P108 "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202" @default.
- NCIT_C187050 NCIT_P208 "CL1779206" @default.
- NCIT_C187050 NCIT_P322 "GDC" @default.
- NCIT_C187050 NCIT_P399 "809332" @default.
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- NCIT_C187050 hasExactSynonym "Autologous TILs GT202" @default.
- NCIT_C187050 hasExactSynonym "Autologous mbIL-12-expressing TILs GT202" @default.
- NCIT_C187050 hasExactSynonym "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202" @default.
- NCIT_C187050 hasExactSynonym "GT 202" @default.
- NCIT_C187050 hasExactSynonym "GT-202" @default.
- NCIT_C187050 hasExactSynonym "GT202" @default.
- NCIT_C187050 inSubset NCIT_C128784 @default.
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- NCIT_C187050 type Class @default.
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- NCIT_C187050 label "Autologous mbIL-12-expressing Tumor Infiltrating Lymphocytes GT202" @default.
- NCIT_C187050 subClassOf NCIT_C129820 @default.
- NCIT_C187050 subClassOf NCIT_C129821 @default.
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- NCIT_C187050 subClassOf NCIT_C1909 @default.
- NCIT_C187050 subClassOf NCIT_C201547 @default.
- NCIT_C187050 subClassOf NCIT_C274 @default.
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- NCIT_C187050 subClassOf NCIT_C307 @default.
- NCIT_C187050 subClassOf NCIT_C308 @default.