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- NCIT_C187109 IAO_0000115 "A bispecific antibody directed against the tumor-associated antigen (TAA) glypican-3 (GPC3; GPC-3) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3/anti-CD3 bispecific antibody CM350 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and GPC3 on GPC3-expressing tumor cells. This activates and redirects CTLs to GPC3-expressing tumor cells, leading to CTL-mediated killing of GPC3-expressing tumor cells. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells. GPC3 plays an important role in tumor cell proliferation in various tumor cell types." @default.
- NCIT_C187109 NCIT_A7 NCIT_C88175 @default.
- NCIT_C187109 NCIT_NHC0 "C187109" @default.
- NCIT_C187109 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187109 NCIT_P108 "Anti-GPC3/Anti-CD3 Bispecific Antibody CM350" @default.
- NCIT_C187109 NCIT_P208 "CL1792021" @default.
- NCIT_C187109 NCIT_P322 "GDC" @default.
- NCIT_C187109 NCIT_P399 "809381" @default.
- NCIT_C187109 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187109 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187109 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187109 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187109 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187109 normalizedInformationContent "100" @default.
- NCIT_C187109 referenceCount "1" @default.
- NCIT_C187109 hasExactSynonym "Anti-GPC3/Anti-CD3 Bispecific Antibody CM350" @default.
- NCIT_C187109 hasExactSynonym "Anti-GPC3/CD3 Bispecific Antibody CM350" @default.
- NCIT_C187109 hasExactSynonym "CM 350" @default.
- NCIT_C187109 hasExactSynonym "CM-350" @default.
- NCIT_C187109 hasExactSynonym "CM350" @default.
- NCIT_C187109 hasExactSynonym "GPC3 x CD3 Bispecific Antibody CM350" @default.
- NCIT_C187109 inSubset NCIT_C128784 @default.
- NCIT_C187109 inSubset NCIT_C157711 @default.
- NCIT_C187109 inSubset NCIT_C157712 @default.
- NCIT_C187109 inSubset NCIT_C176424 @default.
- NCIT_C187109 type Class @default.
- NCIT_C187109 isDefinedBy ncit.owl @default.
- NCIT_C187109 label "Anti-GPC3/Anti-CD3 Bispecific Antibody CM350" @default.
- NCIT_C187109 subClassOf NCIT_C112883 @default.
- NCIT_C187109 subClassOf NCIT_C129821 @default.
- NCIT_C187109 subClassOf NCIT_C129822 @default.
- NCIT_C187109 subClassOf NCIT_C1454 @default.
- NCIT_C187109 subClassOf NCIT_C187109 @default.
- NCIT_C187109 subClassOf NCIT_C1908 @default.
- NCIT_C187109 subClassOf NCIT_C1909 @default.
- NCIT_C187109 subClassOf NCIT_C201282 @default.
- NCIT_C187109 subClassOf NCIT_C20401 @default.
- NCIT_C187109 subClassOf NCIT_C274 @default.
- NCIT_C187109 subClassOf NCIT_C28227 @default.
- NCIT_C187109 subClassOf NCIT_C307 @default.
- NCIT_C187109 subClassOf NCIT_C308 @default.