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- NCIT_C187110 IAO_0000115 "A human immunoglobulin (Ig) G1 monoclonal antibody directed against the CD25 subunit-interacting domain of the cytokine interleukin-2 (IL-2; IL2), with potential immunomodulatory activity. Upon administration, anti-CD25-IL2 monoclonal antibody AU-007 targets, binds to and blocks the CD25 subunit-interacting domain of IL-2, thereby blocking the binding of IL-2 to the CD25 subunit (IL-2 receptor subunit alpha; IL-2Ralpha) of the human trimeric IL-2 receptor (IL-2R) expressed on the surface of regulatory T-lymphocytes (Tregs), thereby inhibiting IL-2Ralpha-mediated Tregs activation. This may prevent Treg-mediated immunosuppression. As the ability of IL-2 to bind to dimeric CD122 (IL-2Rbeta)/CD132 receptor is preserved, AU-007 promotes immune effector activation by IL-2 via IL-2-mediated signaling through the dimeric IL-2R. This may active an anti-tumor immune response against tumor cells through activation of T-lymphocytes, natural killer (NK) cells, and NK T-cells, thereby killing cancer cells. In addition, by blocking the binding of IL-2 to CD25 expressed on vascular endothelium and smooth muscle cells and subsequent activation, exacerbation of vascular leak syndrome (VLS) is prevented. IL-2 binds to the IL-2R dimeric receptor expressed on CD8 T effector cells, memory T cells, NK cells and NKT cells and is composed of CD122 and CD132. The IL-2R trimeric receptor expressed on Tregs and vascular endothelium is composed of CD25, CD122 and CD132." @default.
- NCIT_C187110 NCIT_A7 NCIT_C26267 @default.
- NCIT_C187110 NCIT_NHC0 "C187110" @default.
- NCIT_C187110 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187110 NCIT_P108 "Anti-CD25-IL-2 Monoclonal Antibody AU-007" @default.
- NCIT_C187110 NCIT_P208 "CL1792022" @default.
- NCIT_C187110 NCIT_P322 "GDC" @default.
- NCIT_C187110 NCIT_P399 "809382" @default.
- NCIT_C187110 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187110 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187110 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187110 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187110 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187110 normalizedInformationContent "100" @default.
- NCIT_C187110 referenceCount "1" @default.
- NCIT_C187110 hasExactSynonym "AU 007" @default.
- NCIT_C187110 hasExactSynonym "AU-007" @default.
- NCIT_C187110 hasExactSynonym "AU007" @default.
- NCIT_C187110 hasExactSynonym "Anti-CD25-IL-2 Monoclonal Antibody AU-007" @default.
- NCIT_C187110 inSubset NCIT_C128784 @default.
- NCIT_C187110 inSubset NCIT_C157711 @default.
- NCIT_C187110 inSubset NCIT_C157712 @default.
- NCIT_C187110 inSubset NCIT_C176424 @default.
- NCIT_C187110 type Class @default.
- NCIT_C187110 isDefinedBy ncit.owl @default.
- NCIT_C187110 label "Anti-CD25-IL-2 Monoclonal Antibody AU-007" @default.
- NCIT_C187110 subClassOf NCIT_C129821 @default.
- NCIT_C187110 subClassOf NCIT_C129822 @default.
- NCIT_C187110 subClassOf NCIT_C187110 @default.
- NCIT_C187110 subClassOf NCIT_C1908 @default.
- NCIT_C187110 subClassOf NCIT_C1909 @default.
- NCIT_C187110 subClassOf NCIT_C20401 @default.
- NCIT_C187110 subClassOf NCIT_C274 @default.
- NCIT_C187110 subClassOf NCIT_C307 @default.
- NCIT_C187110 subClassOf NCIT_C308 @default.