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- NCIT_C187116 IAO_0000115 "A polymeric nanoparticle formulation of the topoisomerase I inhibitor camptothecin (CPT), an alkaloid isolated from the Chinese tree Camptotheca acuminata, covalently conjugated, via a linker, to a biocompatible polymer scaffold, with potential antineoplastic activity. Upon intravenous administration of polymeric nanoparticle-conjugated CPT DAN-222, the nanoparticles accumulate in tumor tissue and CPT is released from the formulation at the tumor site and taken up by tumor cells. During the S phase of the cell cycle, CPT selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Compared to CPT alone, the nanoparticle formulation has a prolonged half-life and greatly improves the biodistribution of CPT resulting in an accumulation of CPT at the tumor site, which enhances tumor exposure while greatly reducing toxic side effects." @default.
- NCIT_C187116 NCIT_A7 NCIT_C16516 @default.
- NCIT_C187116 NCIT_NHC0 "C187116" @default.
- NCIT_C187116 NCIT_P106 "Organic Chemical" @default.
- NCIT_C187116 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187116 NCIT_P107 "Polymeric Nanoparticle-conjugated Camptothecin DAN-222" @default.
- NCIT_C187116 NCIT_P108 "Polymeric Nanoparticle-conjugated Camptothecin DAN-222" @default.
- NCIT_C187116 NCIT_P208 "CL1792032" @default.
- NCIT_C187116 NCIT_P322 "CTRP" @default.
- NCIT_C187116 NCIT_P322 "GDC" @default.
- NCIT_C187116 NCIT_P399 "809389" @default.
- NCIT_C187116 normalizedInformationContent "100" @default.
- NCIT_C187116 referenceCount "1" @default.
- NCIT_C187116 hasExactSynonym "DAN 222" @default.
- NCIT_C187116 hasExactSynonym "DAN-222" @default.
- NCIT_C187116 hasExactSynonym "DAN222" @default.
- NCIT_C187116 hasExactSynonym "Polymeric Nanoparticle-conjugated Camptothecin DAN-222" @default.
- NCIT_C187116 hasExactSynonym "Polymeric Nanoparticle-containing Camptothecin DAN-222" @default.
- NCIT_C187116 hasExactSynonym "Polymeric Nanoparticles DAN-222" @default.
- NCIT_C187116 inSubset NCIT_C116977 @default.
- NCIT_C187116 inSubset NCIT_C116978 @default.
- NCIT_C187116 inSubset NCIT_C128784 @default.
- NCIT_C187116 inSubset NCIT_C157711 @default.
- NCIT_C187116 inSubset NCIT_C157712 @default.
- NCIT_C187116 inSubset NCIT_C176424 @default.
- NCIT_C187116 type Class @default.
- NCIT_C187116 isDefinedBy ncit.owl @default.
- NCIT_C187116 label "Polymeric Nanoparticle-conjugated Camptothecin DAN-222" @default.
- NCIT_C187116 subClassOf NCIT_C129824 @default.
- NCIT_C187116 subClassOf NCIT_C129825 @default.
- NCIT_C187116 subClassOf NCIT_C1748 @default.
- NCIT_C187116 subClassOf NCIT_C187116 @default.
- NCIT_C187116 subClassOf NCIT_C1904 @default.
- NCIT_C187116 subClassOf NCIT_C1908 @default.
- NCIT_C187116 subClassOf NCIT_C1909 @default.
- NCIT_C187116 subClassOf NCIT_C2189 @default.
- NCIT_C187116 subClassOf NCIT_C274 @default.
- NCIT_C187116 subClassOf NCIT_C2843 @default.
- NCIT_C187116 subClassOf NCIT_C471 @default.