Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187120> ?p ?o ?g. }
Showing items 1 to 33 of
33
with 100 items per page.
- NCIT_C187120 IAO_0000115 "A humanized monoclonal antibody directed against the bone morphogenetic proteins (BMPs) co-receptor hemojuvelin (HJV), with potential to treat anemia of inflammation and other forms of anemia. Upon subcutaneous administration, anti-HJV monoclonal antibody DISC-0974 targets and binds to HJV, preventing it from binding to the hepcidin regulatory ligands BMPs and inhibiting the HJV-mediated signaling pathway. This suppresses hepcidin synthesis and increases iron availability, which may normalize plasma iron levels and increase erythropoiesis. HJV is required for hepcidin production. Hepcidin plays a key role in the homeostasis of systemic iron by restricting iron absorption and inhibiting ferroportin-mediated iron export; it is upregulated during acute and chronic inflammation in response to cytokines and, in certain cancers, may contribute to cancer-associated anemia." @default.
- NCIT_C187120 NCIT_A7 NCIT_C113604 @default.
- NCIT_C187120 NCIT_NHC0 "C187120" @default.
- NCIT_C187120 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187120 NCIT_P107 "Anti-HJV Monoclonal Antibody DISC-0974" @default.
- NCIT_C187120 NCIT_P108 "Anti-HJV Monoclonal Antibody DISC-0974" @default.
- NCIT_C187120 NCIT_P208 "CL1792028" @default.
- NCIT_C187120 NCIT_P322 "CTRP" @default.
- NCIT_C187120 NCIT_P399 "809435" @default.
- NCIT_C187120 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187120 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187120 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187120 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187120 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187120 normalizedInformationContent "100" @default.
- NCIT_C187120 referenceCount "1" @default.
- NCIT_C187120 hasExactSynonym "Anti-HJV Monoclonal Antibody DISC-0974" @default.
- NCIT_C187120 hasExactSynonym "Anti-Hemojuvelin Monoclonal Antibody DISC-0974" @default.
- NCIT_C187120 hasExactSynonym "DISC 0974" @default.
- NCIT_C187120 hasExactSynonym "DISC-0974" @default.
- NCIT_C187120 hasExactSynonym "DISC0974" @default.
- NCIT_C187120 inSubset NCIT_C116977 @default.
- NCIT_C187120 inSubset NCIT_C116978 @default.
- NCIT_C187120 inSubset NCIT_C176424 @default.
- NCIT_C187120 type Class @default.
- NCIT_C187120 isDefinedBy ncit.owl @default.
- NCIT_C187120 label "Anti-HJV Monoclonal Antibody DISC-0974" @default.
- NCIT_C187120 subClassOf NCIT_C187120 @default.
- NCIT_C187120 subClassOf NCIT_C1908 @default.
- NCIT_C187120 subClassOf NCIT_C1909 @default.
- NCIT_C187120 subClassOf NCIT_C20401 @default.
- NCIT_C187120 subClassOf NCIT_C307 @default.
- NCIT_C187120 subClassOf NCIT_C308 @default.