Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187124> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- NCIT_C187124 IAO_0000115 "A lipid nanoparticle (LNP) encapsulating nucleoside-modified messenger RNA (mRNA) encoding for bispecific antibody directed against the tumor-associated antigen (TAA) Claudin 6 (CLDN6; CLDN-6) and the human T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, mRNA-encoded anti-CD3/anti-CLDN6 bispecific antibody BNT142 binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is translated and the anti-CD3/anti-CLDN6 bispecific antibody binds to both CD3-expressing T-cells and CLDN6-expressing cancer cells, thereby crosslinking CLDN6-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CLDN6-expressing tumor cells. CLDN6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not expressed on normal, healthy adult cells." @default.
- NCIT_C187124 NCIT_NHC0 "C187124" @default.
- NCIT_C187124 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C187124 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187124 NCIT_P107 "mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142" @default.
- NCIT_C187124 NCIT_P108 "mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142" @default.
- NCIT_C187124 NCIT_P208 "CL1792008" @default.
- NCIT_C187124 NCIT_P322 "CTRP" @default.
- NCIT_C187124 NCIT_P322 "GDC" @default.
- NCIT_C187124 NCIT_P399 "809400" @default.
- NCIT_C187124 NCIT_R124 NCIT_C17710 @default.
- NCIT_C187124 NCIT_R124 NCIT_C17828 @default.
- NCIT_C187124 NCIT_R124 NCIT_C18219 @default.
- NCIT_C187124 NCIT_R124 NCIT_C19986 @default.
- NCIT_C187124 NCIT_R124 NCIT_C40474 @default.
- NCIT_C187124 normalizedInformationContent "100" @default.
- NCIT_C187124 referenceCount "1" @default.
- NCIT_C187124 hasExactSynonym "Anti-CD3/Anti-CLDN6 mRNA-encoded Antibody BNT142" @default.
- NCIT_C187124 hasExactSynonym "Anti-CD33/CD3 Antibody GEM 333" @default.
- NCIT_C187124 hasExactSynonym "BNT 142" @default.
- NCIT_C187124 hasExactSynonym "BNT-142" @default.
- NCIT_C187124 hasExactSynonym "BNT142" @default.
- NCIT_C187124 hasExactSynonym "CD3 x CLDN6 mRNA-encoded Antibody BNT142" @default.
- NCIT_C187124 hasExactSynonym "CD3xCLDN6 RiboMAB-encoding mRNA BNT142" @default.
- NCIT_C187124 hasExactSynonym "RiboMab BNT142" @default.
- NCIT_C187124 hasExactSynonym "mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142" @default.
- NCIT_C187124 hasExactSynonym "rMAB BNT142" @default.
- NCIT_C187124 inSubset NCIT_C116977 @default.
- NCIT_C187124 inSubset NCIT_C116978 @default.
- NCIT_C187124 inSubset NCIT_C128784 @default.
- NCIT_C187124 inSubset NCIT_C157711 @default.
- NCIT_C187124 inSubset NCIT_C157712 @default.
- NCIT_C187124 inSubset NCIT_C176424 @default.
- NCIT_C187124 type Class @default.
- NCIT_C187124 isDefinedBy ncit.owl @default.
- NCIT_C187124 label "mRNA-encoded Anti-CD3/Anti-CLDN6 Bispecific Antibody BNT142" @default.
- NCIT_C187124 subClassOf NCIT_C112883 @default.
- NCIT_C187124 subClassOf NCIT_C129821 @default.
- NCIT_C187124 subClassOf NCIT_C129822 @default.
- NCIT_C187124 subClassOf NCIT_C1454 @default.
- NCIT_C187124 subClassOf NCIT_C187124 @default.
- NCIT_C187124 subClassOf NCIT_C1908 @default.
- NCIT_C187124 subClassOf NCIT_C1909 @default.
- NCIT_C187124 subClassOf NCIT_C201282 @default.
- NCIT_C187124 subClassOf NCIT_C20401 @default.
- NCIT_C187124 subClassOf NCIT_C274 @default.
- NCIT_C187124 subClassOf NCIT_C28227 @default.
- NCIT_C187124 subClassOf NCIT_C307 @default.
- NCIT_C187124 subClassOf NCIT_C308 @default.