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- NCIT_C187125 IAO_0000115 "A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s) (CAR) targeting the human tumor-associated antigens (TAAs) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and G-protein coupled receptor family C group 5 member D (GPRC5D) and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-BCMA/anti-GPRC5D CAR-T cells OriC321 specifically and simultaneously target and bind to tumor cells expressing BCMA and/or GPRC5D. This induces selective toxicity in tumor cells that express BCMA and/or GPRC5D. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation." @default.
- NCIT_C187125 NCIT_A7 NCIT_C147936 @default.
- NCIT_C187125 NCIT_A7 NCIT_C97848 @default.
- NCIT_C187125 NCIT_NHC0 "C187125" @default.
- NCIT_C187125 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187125 NCIT_P108 "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321" @default.
- NCIT_C187125 NCIT_P208 "CL1792005" @default.
- NCIT_C187125 NCIT_P322 "GDC" @default.
- NCIT_C187125 NCIT_P399 "809436" @default.
- NCIT_C187125 normalizedInformationContent "100" @default.
- NCIT_C187125 referenceCount "1" @default.
- NCIT_C187125 hasExactSynonym "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321" @default.
- NCIT_C187125 hasExactSynonym "BCMA/GPRC5D Dual Target CAR-T Cells OriC321" @default.
- NCIT_C187125 hasExactSynonym "BCMA/GPRC5D-targeted CAR T-cells OriC321" @default.
- NCIT_C187125 hasExactSynonym "Bispecific BCMA/GPRC5D-targeted CAR T Cells OriC321" @default.
- NCIT_C187125 hasExactSynonym "OriC 321" @default.
- NCIT_C187125 hasExactSynonym "OriC-321" @default.
- NCIT_C187125 hasExactSynonym "OriC321" @default.
- NCIT_C187125 inSubset NCIT_C128784 @default.
- NCIT_C187125 inSubset NCIT_C157711 @default.
- NCIT_C187125 inSubset NCIT_C157712 @default.
- NCIT_C187125 inSubset NCIT_C176424 @default.
- NCIT_C187125 type Class @default.
- NCIT_C187125 isDefinedBy ncit.owl @default.
- NCIT_C187125 label "Anti-BCMA/Anti-GPRC5D CAR-T Cells OriC321" @default.
- NCIT_C187125 subClassOf NCIT_C129820 @default.
- NCIT_C187125 subClassOf NCIT_C129821 @default.
- NCIT_C187125 subClassOf NCIT_C129826 @default.
- NCIT_C187125 subClassOf NCIT_C137999 @default.
- NCIT_C187125 subClassOf NCIT_C142078 @default.
- NCIT_C187125 subClassOf NCIT_C154231 @default.
- NCIT_C187125 subClassOf NCIT_C176023 @default.
- NCIT_C187125 subClassOf NCIT_C187125 @default.
- NCIT_C187125 subClassOf NCIT_C1908 @default.
- NCIT_C187125 subClassOf NCIT_C1909 @default.
- NCIT_C187125 subClassOf NCIT_C1962 @default.
- NCIT_C187125 subClassOf NCIT_C274 @default.
- NCIT_C187125 subClassOf NCIT_C307 @default.
- NCIT_C187125 subClassOf NCIT_C308 @default.