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- NCIT_C187159 IAO_0000115 "An orally available, small molecule inhibitor of the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, PD-L1 inhibitor AN4005 specifically targets and binds to PD-L1 expressed on tumor cells, thereby preventing the binding of PD-L1 to and subsequent activation of its receptor programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells." @default.
- NCIT_C187159 NCIT_A7 NCIT_C96024 @default.
- NCIT_C187159 NCIT_NHC0 "C187159" @default.
- NCIT_C187159 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187159 NCIT_P107 "PD-L1 Inhibitor AN4005" @default.
- NCIT_C187159 NCIT_P108 "PD-L1 Inhibitor AN4005" @default.
- NCIT_C187159 NCIT_P208 "CL1791914" @default.
- NCIT_C187159 NCIT_P322 "CTRP" @default.
- NCIT_C187159 NCIT_P322 "GDC" @default.
- NCIT_C187159 normalizedInformationContent "100" @default.
- NCIT_C187159 referenceCount "1" @default.
- NCIT_C187159 hasExactSynonym "AN 4005" @default.
- NCIT_C187159 hasExactSynonym "AN-4005" @default.
- NCIT_C187159 hasExactSynonym "AN4005" @default.
- NCIT_C187159 hasExactSynonym "PD-L1 Inhibitor AN4005" @default.
- NCIT_C187159 inSubset NCIT_C116977 @default.
- NCIT_C187159 inSubset NCIT_C116978 @default.
- NCIT_C187159 inSubset NCIT_C128784 @default.
- NCIT_C187159 inSubset NCIT_C157711 @default.
- NCIT_C187159 inSubset NCIT_C157712 @default.
- NCIT_C187159 inSubset NCIT_C176424 @default.
- NCIT_C187159 type Class @default.
- NCIT_C187159 isDefinedBy ncit.owl @default.
- NCIT_C187159 label "PD-L1 Inhibitor AN4005" @default.
- NCIT_C187159 subClassOf NCIT_C141144 @default.
- NCIT_C187159 subClassOf NCIT_C143250 @default.
- NCIT_C187159 subClassOf NCIT_C156893 @default.
- NCIT_C187159 subClassOf NCIT_C163758 @default.
- NCIT_C187159 subClassOf NCIT_C187159 @default.
- NCIT_C187159 subClassOf NCIT_C1908 @default.
- NCIT_C187159 subClassOf NCIT_C1909 @default.
- NCIT_C187159 subClassOf NCIT_C191689 @default.
- NCIT_C187159 subClassOf NCIT_C274 @default.
- NCIT_C187159 subClassOf NCIT_C308 @default.