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- NCIT_C187289 IAO_0000115 "An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunomodulatory and antineoplastic activities. Upon administration, anti-OX40 agonist monoclonal antibody HFB301001 selectively targets and binds to a unique epitope on OX40, and activates OX40 without competing with the endogenous OX40 ligand (OX40L; tumor necrosis factor ligand superfamily member 4; TNFSF4). This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME), thereby enhancing anti-tumor immune responses and preventing Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation. HFB301001 does not lead to a downregulation of OX40 following the co-stimulation of T-cells." @default.
- NCIT_C187289 NCIT_A7 NCIT_C94790 @default.
- NCIT_C187289 NCIT_NHC0 "C187289" @default.
- NCIT_C187289 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C187289 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C187289 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187289 NCIT_P107 "Anti-OX40 Agonist Monoclonal Antibody HFB301001" @default.
- NCIT_C187289 NCIT_P108 "Anti-OX40 Agonist Monoclonal Antibody HFB301001" @default.
- NCIT_C187289 NCIT_P208 "CL1792206" @default.
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- NCIT_C187289 hasExactSynonym "Agonistic Anti-OX40 Monoclonal Antibody HFB301001" @default.
- NCIT_C187289 hasExactSynonym "Anti-OX40 Agonist Monoclonal Antibody HFB301001" @default.
- NCIT_C187289 hasExactSynonym "HFB 301001" @default.
- NCIT_C187289 hasExactSynonym "HFB-301001" @default.
- NCIT_C187289 hasExactSynonym "HFB301001" @default.
- NCIT_C187289 inSubset NCIT_C116977 @default.
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- NCIT_C187289 type Class @default.
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- NCIT_C187289 label "Anti-OX40 Agonist Monoclonal Antibody HFB301001" @default.
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- NCIT_C187289 subClassOf NCIT_C96040 @default.