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- NCIT_C1873 IAO_0000115 "A 1,1-bisphosphonate ester with potential antineoplastic and hypocholesterolemic activities. SR-45023A binds to hydroxyapatite crystals in the bone matrix where it inhibits enzymatic activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which is required for the formation of mevalonate, the precursor of cholesterol. Consequently, shortage of mevalonate impedes the synthesis of downstream isoprenoids that are essential for protein prenylation. This leads to the loss of activity of proteins involved in osteoclast function and cellular proliferation, such as Ras and Rho, leading to an inhibition of cellular proliferation, and induction of osteoclasts apoptosis. In addition, SR-45023A activates the farnesoid X activated receptor (FXR), a member of the nuclear hormone superfamily implicated in cholesterol metabolism and bile acid transport and may play a role in this agent's antineoplastic effect." @default.
- NCIT_C1873 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1873 NCIT_NHC0 "C1873" @default.
- NCIT_C1873 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1873 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1873 NCIT_P108 "Apomine" @default.
- NCIT_C1873 NCIT_P207 "C0766100" @default.
- NCIT_C1873 NCIT_P210 "126411-13-0" @default.
- NCIT_C1873 NCIT_P319 "JQ95208805" @default.
- NCIT_C1873 NCIT_P322 "FDA" @default.
- NCIT_C1873 NCIT_P322 "GDC" @default.
- NCIT_C1873 NCIT_P325 "An anticancer drug that belongs to the family of drugs called bisphosphonates. It affects cancer cell receptors governing cell growth and cell death." @default.
- NCIT_C1873 NCIT_P329 "43447" @default.
- NCIT_C1873 NCIT_P330 "43447" @default.
- NCIT_C1873 NCIT_P350 "C28H52O7P2" @default.
- NCIT_C1873 NCIT_P366 "SR-45023A" @default.
- NCIT_C1873 NCIT_P375 "Apomine" @default.
- NCIT_C1873 NCIT_P399 "43447" @default.
- NCIT_C1873 normalizedInformationContent "100" @default.
- NCIT_C1873 referenceCount "1" @default.
- NCIT_C1873 hasExactSynonym "Apomine" @default.
- NCIT_C1873 hasExactSynonym "Phosphonic acid, (2-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)ethylidene)bis-, tetrakis(1-methylethyl) Ester" @default.
- NCIT_C1873 hasExactSynonym "SKF 99085" @default.
- NCIT_C1873 hasExactSynonym "SR-45023A (Apomine)" @default.
- NCIT_C1873 hasExactSynonym "SR-45023A" @default.
- NCIT_C1873 hasExactSynonym "TETRAISOPROPYL 2-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)ETHYL-1,1-BIPHOSPHONATE" @default.
- NCIT_C1873 hasExactSynonym "Tetraisopropyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethylidene-1,1-diphosphonate" @default.
- NCIT_C1873 inSubset NCIT_C128784 @default.
- NCIT_C1873 inSubset NCIT_C157711 @default.
- NCIT_C1873 inSubset NCIT_C157712 @default.
- NCIT_C1873 inSubset NCIT_C176424 @default.
- NCIT_C1873 inSubset NCIT_C177537 @default.
- NCIT_C1873 inSubset NCIT_C63923 @default.
- NCIT_C1873 type Class @default.
- NCIT_C1873 isDefinedBy ncit.owl @default.
- NCIT_C1873 label "Apomine" @default.
- NCIT_C1873 subClassOf NCIT_C1873 @default.
- NCIT_C1873 subClassOf NCIT_C1908 @default.
- NCIT_C1873 subClassOf NCIT_C1909 @default.
- NCIT_C1873 subClassOf NCIT_C1913 @default.
- NCIT_C1873 subClassOf NCIT_C443 @default.
- NCIT_C1873 subClassOf NCIT_C67439 @default.
- NCIT_C1873 subClassOf NCIT_C718 @default.
- NCIT_C1873 subClassOf NCIT_C78281 @default.