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- NCIT_C187301 IAO_0000115 "A preparation of allogeneic natural killer (NK) cells derived from a clonal master induced pluripotent stem cell (iPSC) line, and engineered to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) derived from the anti-CD19 monoclonal antibody FMC63 and coupled to the CD28 and zeta chain of the TCR/CD3 complex (CD3-zeta) costimulatory signaling domains, and interleukin 15 (IL-15), with potential immunostimulatory and antineoplastic activities. Upon administration, allogeneic iPSC-derived anti-CD19-CAR/IL-15-expressing NK cells CNTY-101 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The human tumor associated antigen (TAA) CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CNTY-101 is also engineered with a safety switch composed of a shorter version of the extracellular domain of human epidermal growth factor receptor (EGFR). This allows the elimination of CNTY-101 upon the administration of anti-EGFR antibodies such as cetuximab. In addition, CNTY-101 is gene-edited to prevent its elimination by the patient's NK cells, CD4 and CD8 T-cells." @default.
- NCIT_C187301 NCIT_A7 NCIT_C38894 @default.
- NCIT_C187301 NCIT_NHC0 "C187301" @default.
- NCIT_C187301 NCIT_P106 "Cell" @default.
- NCIT_C187301 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187301 NCIT_P107 "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101" @default.
- NCIT_C187301 NCIT_P108 "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101" @default.
- NCIT_C187301 NCIT_P208 "CL1792248" @default.
- NCIT_C187301 NCIT_P322 "CTRP" @default.
- NCIT_C187301 NCIT_P322 "GDC" @default.
- NCIT_C187301 NCIT_P399 "809535" @default.
- NCIT_C187301 normalizedInformationContent "100" @default.
- NCIT_C187301 referenceCount "1" @default.
- NCIT_C187301 hasExactSynonym "Allogeneic Anti-CD19-CAR-iNK Cells CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "Allogeneic Anti-CD19-CAR-iPSC-derived Natural Killer Cells CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "Allogeneic iPSC-derived Anti-CD19-CAR-CD28-CD3zeta-IL-15-expressing NK Cells CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing Natural Killer Cells CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "CNTY 101" @default.
- NCIT_C187301 hasExactSynonym "CNTY-101" @default.
- NCIT_C187301 hasExactSynonym "CNTY101" @default.
- NCIT_C187301 inSubset NCIT_C116977 @default.
- NCIT_C187301 inSubset NCIT_C116978 @default.
- NCIT_C187301 inSubset NCIT_C128784 @default.
- NCIT_C187301 inSubset NCIT_C157711 @default.
- NCIT_C187301 inSubset NCIT_C157712 @default.
- NCIT_C187301 inSubset NCIT_C176424 @default.
- NCIT_C187301 type Class @default.
- NCIT_C187301 isDefinedBy ncit.owl @default.
- NCIT_C187301 label "Allogeneic iPSC-derived Anti-CD19-CAR/IL-15-expressing NK Cells CNTY-101" @default.
- NCIT_C187301 subClassOf NCIT_C129820 @default.
- NCIT_C187301 subClassOf NCIT_C129821 @default.
- NCIT_C187301 subClassOf NCIT_C129826 @default.
- NCIT_C187301 subClassOf NCIT_C142078 @default.
- NCIT_C187301 subClassOf NCIT_C187301 @default.
- NCIT_C187301 subClassOf NCIT_C1908 @default.
- NCIT_C187301 subClassOf NCIT_C1909 @default.
- NCIT_C187301 subClassOf NCIT_C201545 @default.
- NCIT_C187301 subClassOf NCIT_C274 @default.
- NCIT_C187301 subClassOf NCIT_C28676 @default.
- NCIT_C187301 subClassOf NCIT_C307 @default.
- NCIT_C187301 subClassOf NCIT_C308 @default.