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- NCIT_C187313 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) linked to an as of yet undisclosed tubulin inhibitor, with potential antineoplastic activity. Upon administration of anti-TROP2 ADC BIO-106, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon binding and internalization, the tubulin inhibitor is released, and binds to tubulin and inhibits its polymerization. This results in G2/M phase arrest and apoptosis, and inhibits the proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.
- NCIT_C187313 NCIT_A7 NCIT_C18544 @default.
- NCIT_C187313 NCIT_NHC0 "C187313" @default.
- NCIT_C187313 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187313 NCIT_P107 "Anti-TROP2 Antibody-drug Conjugate BIO-106" @default.
- NCIT_C187313 NCIT_P108 "Anti-TROP2 Antibody-drug Conjugate BIO-106" @default.
- NCIT_C187313 NCIT_P208 "CL1792252" @default.
- NCIT_C187313 NCIT_P322 "CTRP" @default.
- NCIT_C187313 NCIT_P322 "GDC" @default.
- NCIT_C187313 NCIT_P399 "809529" @default.
- NCIT_C187313 normalizedInformationContent "100" @default.
- NCIT_C187313 referenceCount "1" @default.
- NCIT_C187313 hasExactSynonym "Anti-TROP2 ADC BIO-106" @default.
- NCIT_C187313 hasExactSynonym "Anti-TROP2 Antibody-drug Conjugate BIO-106" @default.
- NCIT_C187313 hasExactSynonym "BIO 106" @default.
- NCIT_C187313 hasExactSynonym "BIO-106" @default.
- NCIT_C187313 hasExactSynonym "BIO106" @default.
- NCIT_C187313 inSubset NCIT_C116977 @default.
- NCIT_C187313 inSubset NCIT_C116978 @default.
- NCIT_C187313 inSubset NCIT_C128784 @default.
- NCIT_C187313 inSubset NCIT_C157711 @default.
- NCIT_C187313 inSubset NCIT_C157712 @default.
- NCIT_C187313 inSubset NCIT_C176424 @default.
- NCIT_C187313 type Class @default.
- NCIT_C187313 isDefinedBy ncit.owl @default.
- NCIT_C187313 label "Anti-TROP2 Antibody-drug Conjugate BIO-106" @default.
- NCIT_C187313 subClassOf NCIT_C129821 @default.
- NCIT_C187313 subClassOf NCIT_C129823 @default.
- NCIT_C187313 subClassOf NCIT_C1512 @default.
- NCIT_C187313 subClassOf NCIT_C187313 @default.
- NCIT_C187313 subClassOf NCIT_C1908 @default.
- NCIT_C187313 subClassOf NCIT_C1909 @default.
- NCIT_C187313 subClassOf NCIT_C200106 @default.
- NCIT_C187313 subClassOf NCIT_C274 @default.
- NCIT_C187313 subClassOf NCIT_C307 @default.
- NCIT_C187313 subClassOf NCIT_C308 @default.