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- NCIT_C187333 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-TROP2 ADC BL-M02D1, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the TROP2-expressing tumor cells, through an as of yet unknown mechanism of action. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.
- NCIT_C187333 NCIT_A7 NCIT_C18544 @default.
- NCIT_C187333 NCIT_NHC0 "C187333" @default.
- NCIT_C187333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187333 NCIT_P108 "Anti-TROP2 Antibody-drug Conjugate BL-M02D1" @default.
- NCIT_C187333 NCIT_P208 "CL1792171" @default.
- NCIT_C187333 NCIT_P322 "GDC" @default.
- NCIT_C187333 NCIT_P399 "809539" @default.
- NCIT_C187333 normalizedInformationContent "100" @default.
- NCIT_C187333 referenceCount "1" @default.
- NCIT_C187333 hasExactSynonym "Anti-TROP2 ADC BL-M02D1" @default.
- NCIT_C187333 hasExactSynonym "Anti-TROP2 Antibody-drug Conjugate BL-M02D1" @default.
- NCIT_C187333 hasExactSynonym "BL M02D1" @default.
- NCIT_C187333 hasExactSynonym "BL-M02D1" @default.
- NCIT_C187333 hasExactSynonym "BLM02D1" @default.
- NCIT_C187333 inSubset NCIT_C128784 @default.
- NCIT_C187333 inSubset NCIT_C157711 @default.
- NCIT_C187333 inSubset NCIT_C157712 @default.
- NCIT_C187333 inSubset NCIT_C176424 @default.
- NCIT_C187333 type Class @default.
- NCIT_C187333 isDefinedBy ncit.owl @default.
- NCIT_C187333 label "Anti-TROP2 Antibody-drug Conjugate BL-M02D1" @default.
- NCIT_C187333 subClassOf NCIT_C129821 @default.
- NCIT_C187333 subClassOf NCIT_C129823 @default.
- NCIT_C187333 subClassOf NCIT_C1512 @default.
- NCIT_C187333 subClassOf NCIT_C187333 @default.
- NCIT_C187333 subClassOf NCIT_C1908 @default.
- NCIT_C187333 subClassOf NCIT_C1909 @default.
- NCIT_C187333 subClassOf NCIT_C200106 @default.
- NCIT_C187333 subClassOf NCIT_C274 @default.
- NCIT_C187333 subClassOf NCIT_C307 @default.
- NCIT_C187333 subClassOf NCIT_C308 @default.