Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C187334> ?p ?o ?g. }
Showing items 1 to 42 of
42
with 100 items per page.
- NCIT_C187334 IAO_0000115 "An orally bioavailable, central nervous system (CNS) penetrating, mutant-selective covalent inhibitor of epidermal growth factor receptor (EGFR; ErbB1) and human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2) alterations, including exon 20 insertion (Ex20ins) mutations, with potential antineoplastic activity. Upon oral administration, EGFR/HER2 inhibitor ORIC-114 selectively targets, irreversibly binds to and inhibits the activity of EGFR or HER2 insertions or mutations. This prevents EGFR/HER2-mediated signaling. This may induce cell death and inhibit tumor growth in EGFR/HER2-overexpressing tumor cells. ORIC-114 is able to penetrate the blood-brain-barrier (BBB) and may therefore exert its activity against EGFR Ex20ins-driven CNS primary tumors and CNS metastases. The ErbB receptor tyrosine kinase family is involved in key cellular functions, including cell growth and survival. EGFR and HER2 alterations constitutively upregulate kinase activity." @default.
- NCIT_C187334 NCIT_A7 NCIT_C17068 @default.
- NCIT_C187334 NCIT_A7 NCIT_C17319 @default.
- NCIT_C187334 NCIT_NHC0 "C187334" @default.
- NCIT_C187334 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187334 NCIT_P107 "EGFR/HER2 Inhibitor ORIC-114" @default.
- NCIT_C187334 NCIT_P108 "EGFR/HER2 Inhibitor ORIC-114" @default.
- NCIT_C187334 NCIT_P208 "CL1792172" @default.
- NCIT_C187334 NCIT_P322 "CTRP" @default.
- NCIT_C187334 NCIT_P322 "GDC" @default.
- NCIT_C187334 NCIT_P399 "809510" @default.
- NCIT_C187334 normalizedInformationContent "100" @default.
- NCIT_C187334 referenceCount "1" @default.
- NCIT_C187334 hasExactSynonym "EGFR/HER2 Inhibitor ORIC-114" @default.
- NCIT_C187334 hasExactSynonym "ORIC 114" @default.
- NCIT_C187334 hasExactSynonym "ORIC-114" @default.
- NCIT_C187334 hasExactSynonym "ORIC114" @default.
- NCIT_C187334 inSubset NCIT_C116977 @default.
- NCIT_C187334 inSubset NCIT_C116978 @default.
- NCIT_C187334 inSubset NCIT_C128784 @default.
- NCIT_C187334 inSubset NCIT_C157711 @default.
- NCIT_C187334 inSubset NCIT_C157712 @default.
- NCIT_C187334 inSubset NCIT_C176424 @default.
- NCIT_C187334 type Class @default.
- NCIT_C187334 isDefinedBy ncit.owl @default.
- NCIT_C187334 label "EGFR/HER2 Inhibitor ORIC-114" @default.
- NCIT_C187334 subClassOf NCIT_C129824 @default.
- NCIT_C187334 subClassOf NCIT_C129825 @default.
- NCIT_C187334 subClassOf NCIT_C1404 @default.
- NCIT_C187334 subClassOf NCIT_C159156 @default.
- NCIT_C187334 subClassOf NCIT_C163758 @default.
- NCIT_C187334 subClassOf NCIT_C163760 @default.
- NCIT_C187334 subClassOf NCIT_C163952 @default.
- NCIT_C187334 subClassOf NCIT_C187334 @default.
- NCIT_C187334 subClassOf NCIT_C1908 @default.
- NCIT_C187334 subClassOf NCIT_C1909 @default.
- NCIT_C187334 subClassOf NCIT_C1967 @default.
- NCIT_C187334 subClassOf NCIT_C199379 @default.
- NCIT_C187334 subClassOf NCIT_C2167 @default.
- NCIT_C187334 subClassOf NCIT_C2189 @default.
- NCIT_C187334 subClassOf NCIT_C274 @default.
- NCIT_C187334 subClassOf NCIT_C471 @default.