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- NCIT_C187336 IAO_0000115 "An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2 inhibitor ABBV-453 targets, binds to and inhibits the activity of Bcl-2. This restores caspase-mediated apoptosis in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis. Its expression is associated with increased drug resistance and tumor cell survival." @default.
- NCIT_C187336 NCIT_A7 NCIT_C153109 @default.
- NCIT_C187336 NCIT_NHC0 "C187336" @default.
- NCIT_C187336 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187336 NCIT_P108 "Bcl-2 Inhibitor ABBV-453" @default.
- NCIT_C187336 NCIT_P208 "CL1792170" @default.
- NCIT_C187336 NCIT_P322 "GDC" @default.
- NCIT_C187336 NCIT_P399 "809512" @default.
- NCIT_C187336 normalizedInformationContent "100" @default.
- NCIT_C187336 referenceCount "1" @default.
- NCIT_C187336 hasExactSynonym "ABBV 453" @default.
- NCIT_C187336 hasExactSynonym "ABBV-453" @default.
- NCIT_C187336 hasExactSynonym "ABBV453" @default.
- NCIT_C187336 hasExactSynonym "Bcl-2 Inhibitor ABBV-453" @default.
- NCIT_C187336 inSubset NCIT_C128784 @default.
- NCIT_C187336 inSubset NCIT_C157711 @default.
- NCIT_C187336 inSubset NCIT_C157712 @default.
- NCIT_C187336 inSubset NCIT_C176424 @default.
- NCIT_C187336 type Class @default.
- NCIT_C187336 isDefinedBy ncit.owl @default.
- NCIT_C187336 label "Bcl-2 Inhibitor ABBV-453" @default.
- NCIT_C187336 subClassOf NCIT_C129839 @default.
- NCIT_C187336 subClassOf NCIT_C159200 @default.
- NCIT_C187336 subClassOf NCIT_C163758 @default.
- NCIT_C187336 subClassOf NCIT_C187336 @default.
- NCIT_C187336 subClassOf NCIT_C1908 @default.
- NCIT_C187336 subClassOf NCIT_C1909 @default.
- NCIT_C187336 subClassOf NCIT_C192025 @default.
- NCIT_C187336 subClassOf NCIT_C274 @default.