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- NCIT_C187337 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR) and the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-EGFR/anti-B7-H3 CAR-T cells target and bind to EGFR-expressing tumor cells and B7-H3-expressing immune and tumor cells, thereby inducing selective toxicity in these cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis." @default.
- NCIT_C187337 NCIT_A7 NCIT_C17068 @default.
- NCIT_C187337 NCIT_A7 NCIT_C93066 @default.
- NCIT_C187337 NCIT_NHC0 "C187337" @default.
- NCIT_C187337 NCIT_P106 "Cell" @default.
- NCIT_C187337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187337 NCIT_P108 "Anti-EGFR/Anti-B7-H3 CAR-T Cells" @default.
- NCIT_C187337 NCIT_P208 "CL1792167" @default.
- NCIT_C187337 NCIT_P399 "809544" @default.
- NCIT_C187337 normalizedInformationContent "100" @default.
- NCIT_C187337 referenceCount "1" @default.
- NCIT_C187337 hasExactSynonym "Anti-EGFR/Anti-B7-H3 CAR-T Cells" @default.
- NCIT_C187337 hasExactSynonym "Anti-EGFR/Anti-B7H3 CAR T Cells" @default.
- NCIT_C187337 hasExactSynonym "Anti-EGFR/Anti-CD276 CAR T-cells" @default.
- NCIT_C187337 hasExactSynonym "EGFR/B7-H3-targeted CAR T Cells" @default.
- NCIT_C187337 inSubset NCIT_C128784 @default.
- NCIT_C187337 inSubset NCIT_C176424 @default.
- NCIT_C187337 type Class @default.
- NCIT_C187337 isDefinedBy ncit.owl @default.
- NCIT_C187337 label "Anti-EGFR/Anti-B7-H3 CAR-T Cells" @default.
- NCIT_C187337 subClassOf NCIT_C129820 @default.
- NCIT_C187337 subClassOf NCIT_C129821 @default.
- NCIT_C187337 subClassOf NCIT_C129826 @default.
- NCIT_C187337 subClassOf NCIT_C137999 @default.
- NCIT_C187337 subClassOf NCIT_C142078 @default.
- NCIT_C187337 subClassOf NCIT_C154231 @default.
- NCIT_C187337 subClassOf NCIT_C187337 @default.
- NCIT_C187337 subClassOf NCIT_C1908 @default.
- NCIT_C187337 subClassOf NCIT_C1909 @default.
- NCIT_C187337 subClassOf NCIT_C1962 @default.
- NCIT_C187337 subClassOf NCIT_C201175 @default.
- NCIT_C187337 subClassOf NCIT_C201492 @default.
- NCIT_C187337 subClassOf NCIT_C274 @default.
- NCIT_C187337 subClassOf NCIT_C307 @default.
- NCIT_C187337 subClassOf NCIT_C308 @default.