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- NCIT_C187340 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody against the tumor-associated antigen (TAA) proto-oncogene c-Met (hepatocyte growth factor receptor; HGFR) site-specifically conjugated to a linker-duocarmycin payload, with potential antineoplastic activity. Upon intravenous administration of anti-c-Met ADC BYON3521, the monoclonal antibody moiety targets and binds to c-Met expressed on tumor cells. Upon binding, the linker is cleaved inside the tumor thereby releasing the duocarmycin payload. Duocarmycin binds to the minor groove of DNA, alkylates adenine at the N3 position, and induces cell death in c-Met-expressing cancer cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis." @default.
- NCIT_C187340 NCIT_A7 NCIT_C18186 @default.
- NCIT_C187340 NCIT_NHC0 "C187340" @default.
- NCIT_C187340 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187340 NCIT_P108 "Anti-c-Met Antibody-drug Conjugate BYON3521" @default.
- NCIT_C187340 NCIT_P208 "CL1792182" @default.
- NCIT_C187340 NCIT_P322 "GDC" @default.
- NCIT_C187340 NCIT_P399 "809513" @default.
- NCIT_C187340 normalizedInformationContent "100" @default.
- NCIT_C187340 referenceCount "1" @default.
- NCIT_C187340 hasExactSynonym "ADC BYON3521" @default.
- NCIT_C187340 hasExactSynonym "Anti-c-Met ADC BYON3521" @default.
- NCIT_C187340 hasExactSynonym "Anti-c-Met Antibody-drug Conjugate BYON3521" @default.
- NCIT_C187340 hasExactSynonym "Anti-c-Met/Duocarmycin Antibody-drug Conjugate BYON3521" @default.
- NCIT_C187340 hasExactSynonym "BYON 3521" @default.
- NCIT_C187340 hasExactSynonym "BYON-3521" @default.
- NCIT_C187340 hasExactSynonym "BYON3521" @default.
- NCIT_C187340 inSubset NCIT_C128784 @default.
- NCIT_C187340 inSubset NCIT_C157711 @default.
- NCIT_C187340 inSubset NCIT_C157712 @default.
- NCIT_C187340 inSubset NCIT_C176424 @default.
- NCIT_C187340 type Class @default.
- NCIT_C187340 isDefinedBy ncit.owl @default.
- NCIT_C187340 label "Anti-c-Met Antibody-drug Conjugate BYON3521" @default.
- NCIT_C187340 subClassOf NCIT_C129821 @default.
- NCIT_C187340 subClassOf NCIT_C129823 @default.
- NCIT_C187340 subClassOf NCIT_C1512 @default.
- NCIT_C187340 subClassOf NCIT_C163758 @default.
- NCIT_C187340 subClassOf NCIT_C164000 @default.
- NCIT_C187340 subClassOf NCIT_C187340 @default.
- NCIT_C187340 subClassOf NCIT_C1908 @default.
- NCIT_C187340 subClassOf NCIT_C1909 @default.
- NCIT_C187340 subClassOf NCIT_C201552 @default.
- NCIT_C187340 subClassOf NCIT_C274 @default.
- NCIT_C187340 subClassOf NCIT_C307 @default.
- NCIT_C187340 subClassOf NCIT_C308 @default.