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- NCIT_C187344 IAO_0000115 "A Fc-enhanced trispecific antibody targeting epidermal growth factor receptor (EGFR) and two different epitopes of hepatocyte growth factor receptor (HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-EGFR/c-Met/c-met trispecific antibody GB263T simultaneously targets and binds to the extracellular domain of both EGFR and two different epitopes on c-Met expressed on tumor cells, thereby preventing receptor phosphorylation and inducing internalization of EGFR and c-Met. This downregulates the expression levels of both EGFR and c-Met proteins and prevents the activation of both EGFR- and c-Met-mediated signaling pathways. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation." @default.
- NCIT_C187344 NCIT_A7 NCIT_C17068 @default.
- NCIT_C187344 NCIT_A7 NCIT_C18186 @default.
- NCIT_C187344 NCIT_NHC0 "C187344" @default.
- NCIT_C187344 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C187344 NCIT_P108 "Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T" @default.
- NCIT_C187344 NCIT_P208 "CL1792178" @default.
- NCIT_C187344 NCIT_P322 "GDC" @default.
- NCIT_C187344 NCIT_P399 "809515" @default.
- NCIT_C187344 normalizedInformationContent "100" @default.
- NCIT_C187344 referenceCount "1" @default.
- NCIT_C187344 hasExactSynonym "Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T" @default.
- NCIT_C187344 hasExactSynonym "EGFR x cMET x cMET Trispecific Antibody GB263T" @default.
- NCIT_C187344 hasExactSynonym "GB 263T" @default.
- NCIT_C187344 hasExactSynonym "GB-263T" @default.
- NCIT_C187344 hasExactSynonym "GB263T" @default.
- NCIT_C187344 hasExactSynonym "Trispecific EGFR/cMET/cMET Antibody GB263T" @default.
- NCIT_C187344 inSubset NCIT_C128784 @default.
- NCIT_C187344 inSubset NCIT_C157711 @default.
- NCIT_C187344 inSubset NCIT_C157712 @default.
- NCIT_C187344 inSubset NCIT_C176424 @default.
- NCIT_C187344 type Class @default.
- NCIT_C187344 isDefinedBy ncit.owl @default.
- NCIT_C187344 label "Anti-EGFR/c-MET/c-MET Trispecific Antibody GB263T" @default.
- NCIT_C187344 subClassOf NCIT_C1454 @default.
- NCIT_C187344 subClassOf NCIT_C187344 @default.
- NCIT_C187344 subClassOf NCIT_C1908 @default.
- NCIT_C187344 subClassOf NCIT_C1909 @default.
- NCIT_C187344 subClassOf NCIT_C307 @default.
- NCIT_C187344 subClassOf NCIT_C308 @default.